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白藜芦醇对三氧化二砷染毒大鼠肺组织砷蓄积的干预作用。

Attenuation of arsenic retention by resveratrol in lung of arsenic trioxide-exposed rats.

机构信息

College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China.

出版信息

Environ Toxicol Pharmacol. 2013 Jul;36(1):35-9. doi: 10.1016/j.etap.2013.02.017. Epub 2013 Mar 4.

DOI:10.1016/j.etap.2013.02.017
PMID:23545367
Abstract

Arsenic trioxide (As2O3) is an important environmental toxin. In this study, the effect of resveratrol on As2O3-induced lung injury in rats is evaluated. The results showed that pre-treatment with resveratrol protected As2O3-induced lung injury by the maintenance of glutathione redox system and decrease in arsenic retention. These suggest supplement with resveratrol may alleviate lung injury in the individuals with chronic exposure to arsenic.

摘要

三氧化二砷（As2O3）是一种重要的环境毒素。本研究评价了白藜芦醇对大鼠砷诱导肺损伤的影响。结果表明，白藜芦醇预处理通过维持谷胱甘肽氧化还原系统和减少砷蓄积来保护砷诱导的肺损伤。这些结果提示补充白藜芦醇可能减轻慢性砷暴露个体的肺损伤。

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Attenuation of arsenic retention by resveratrol in lung of arsenic trioxide-exposed rats.白藜芦醇对三氧化二砷染毒大鼠肺组织砷蓄积的干预作用。
Environ Toxicol Pharmacol. 2013 Jul;36(1):35-9. doi: 10.1016/j.etap.2013.02.017. Epub 2013 Mar 4.
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Resveratrol ameliorates the oxidative damage induced by arsenic trioxide in the feline lung.白藜芦醇可改善三氧化二砷诱导的猫肺氧化损伤。
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Resveratrol, a natural antioxidant, has a protective effect on liver injury induced by inorganic arsenic exposure.白藜芦醇是一种天然抗氧化剂，对无机砷暴露诱导的肝损伤具有保护作用。
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Inorganic arsenic causes cell apoptosis in mouse cerebrum through an oxidative stress-regulated signaling pathway.无机砷通过氧化应激调控的信号通路引起小鼠大脑细胞凋亡。
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Resveratrol attenuates hepatotoxicity of rats exposed to arsenic trioxide.白藜芦醇可减轻三氧化二砷暴露大鼠的肝毒性。
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Resveratrol protects against arsenic trioxide-induced oxidative damage through maintenance of glutathione homeostasis and inhibition of apoptotic progression.白藜芦醇通过维持谷胱甘肽稳态和抑制凋亡进程来预防三氧化二砷诱导的氧化损伤。
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Resveratrol synergistically triggers apoptotic cell death with arsenic trioxide via oxidative stress in human lung adenocarcinoma A549 cells.白藜芦醇通过氧化应激与三氧化二砷协同触发人肺腺癌A549细胞的凋亡性细胞死亡。
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Resveratrol and arsenic trioxide act synergistically to kill tumor cells in vitro and in vivo.白藜芦醇和三氧化二砷协同作用，在体外和体内杀死肿瘤细胞。
PLoS One. 2014 Jun 5;9(6):e98925. doi: 10.1371/journal.pone.0098925. eCollection 2014.

引用本文的文献

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Resveratrol Protects against Cerebral Ischemic Injury via Restraining Lipid Peroxidation, Transition Elements, and Toxic Metal Levels, but Enhancing Anti-Oxidant Activity.白藜芦醇通过抑制脂质过氧化、过渡元素和有毒金属水平，但增强抗氧化活性来预防脑缺血损伤。
Antioxidants (Basel). 2021 Sep 24;10(10):1515. doi: 10.3390/antiox10101515.
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Medicinal plants and natural products in amelioration of arsenic toxicity: a short review.药用植物和天然产物改善砷毒性的研究综述
Pharm Biol. 2017 Dec;55(1):349-354. doi: 10.1080/13880209.2016.1235207.
3
Resveratrol protects against arsenic trioxide-induced oxidative damage through maintenance of glutathione homeostasis and inhibition of apoptotic progression.
白藜芦醇通过维持谷胱甘肽稳态和抑制凋亡进程来预防三氧化二砷诱导的氧化损伤。
Environ Mol Mutagen. 2015 Apr;56(3):333-46. doi: 10.1002/em.21919. Epub 2014 Oct 23.
4
Resveratrol, a natural antioxidant, has a protective effect on liver injury induced by inorganic arsenic exposure.白藜芦醇是一种天然抗氧化剂，对无机砷暴露诱导的肝损伤具有保护作用。
Biomed Res Int. 2014;2014:617202. doi: 10.1155/2014/617202. Epub 2014 Jul 24.