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微卫星标记的信息性

Informativeness of microsatellite markers.

作者信息

Reyes-Valdés M Humberto

机构信息

Department of Plant Breeding, Universidad Autónoma Agraria Antonio Narro, Saltillo, Coahuila, Mexico.

出版信息

Methods Mol Biol. 2013;1006:259-70. doi: 10.1007/978-1-62703-389-3_18.

Abstract

Simple sequence repeats (SSR) are extensively used as genetic markers for studies of diversity, genetic mapping, and cultivar discrimination. The informativeness of a given SSR locus or a loci group depends on the number of alleles, their frequency distribution, as well as the kind of application. Here I describe several methods for calculating marker informativeness, all of them suitable for SSR polymorphisms, proposed by several authors and synthesized in an Information Theory framework. Additionally, free access software resources are described as well as their application through worked examples.

摘要

简单序列重复(SSR)被广泛用作遗传标记,用于多样性研究、遗传图谱构建和品种鉴别。给定SSR位点或位点组的信息含量取决于等位基因的数量、它们的频率分布以及应用类型。在此,我描述了几种计算标记信息含量的方法,所有这些方法都适用于SSR多态性,这些方法由几位作者提出并在信息论框架中进行了综合。此外,还介绍了免费获取的软件资源及其通过实例的应用。

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