Yi C Q, Ma C H, Xie Z P, Cao Y, Zhang G Q, Zhou X K, Liu Z Q
Department of Orthopaedics, Shanghai First People Hospital, Medical School of Shanghai Jiaotong University, Shanghai, China
Genet Mol Res. 2013 Mar 11;12(3):3136-45. doi: 10.4238/2013.March.11.3.
Both rheumatoid arthritis (RA) and osteoarthritis (OA) are complex diseases. Studies and treatment of RA and OA have mainly focused on individual factors. However, there is still no clear understanding of their causes and adequate treatment alternatives are still being sought. We applied gene set-enrichment analysis to microarray datasets of RA and OA to look for regulatory mechanisms. We found 32 highly significant pathways, including 18 downregulated and 14 upregulated pathways associated with RA. We also identified 18 highly significant pathways, including 7 downregulated and 11 up-regulated pathways associated with OA. Several such pathways were found in both RA and OA, including an upregulated PPAR signaling pathway and downregulated leukocyte transendothelial migration. Regulatory mechanisms in RA seem to be more complex than in OA. This information could be useful for diagnosis and treatment of these two diseases.
类风湿性关节炎（RA）和骨关节炎（OA）都是复杂的疾病。对RA和OA的研究及治疗主要集中在个体因素上。然而，人们对其病因仍没有清晰的认识，并且仍在寻找合适的治疗方案。我们将基因集富集分析应用于RA和OA的微阵列数据集，以寻找调控机制。我们发现了32条高度显著的通路，其中包括与RA相关的18条下调通路和14条上调通路。我们还鉴定出18条高度显著的通路，其中包括与OA相关的7条下调通路和11条上调通路。在RA和OA中都发现了几条这样的通路，包括上调的PPAR信号通路和下调的白细胞跨内皮迁移。RA中的调控机制似乎比OA中的更为复杂。这些信息可能对这两种疾病的诊断和治疗有用。
