Squillaci S
Division of Anatomic Pathology, Hospital of Vallecamonica, Esine, BS, Italy.
Pathologica. 2012 Dec;104(6):452-4.
Elastofibroma is a rare soft tissue benign fibrous proliferation that characteristically occurs in periscapular soft tissues of the elderly, particularly in females, with typical morphological features consisting of an admixture of excessive collagen and abnormal elastic fibers displaying a beaded or globular appearance. Here we report an unusual, recently described histological variant with unclear origin, showing the presence of abundant mature fat tissue, named 'elastofibrolipoma', which could lead to confusion with other adipose and mesenchymal cell tumour proliferations. The issue as to whether elastofibrolipoma is reactive or neoplastic, variant of elastofibroma or lipoma, remains controversial. Differential diagnostic problems and histogenetic considerations are provided.
弹力纤维瘤是一种罕见的软组织良性纤维增生,其特征性地发生于老年人的肩胛周软组织,尤其是女性,典型的形态学特征是过多的胶原与呈现串珠状或球状外观的异常弹性纤维混合存在。在此我们报告一种不常见的、最近描述的组织学变异型,其起源不明,表现为存在丰富的成熟脂肪组织,名为“弹力纤维脂肪瘤”,这可能会导致与其他脂肪和间叶细胞肿瘤性增生相混淆。弹力纤维脂肪瘤是反应性的还是肿瘤性的,是弹力纤维瘤的变异型还是脂肪瘤,这个问题仍存在争议。本文提供了鉴别诊断问题及组织发生学方面的考虑。