新生小鼠中白细胞介素-1α和肿瘤坏死因子-α基因的表达
Expression of genes for interleukin-1 alpha and tumour necrosis factor-alpha in newborn mice.
作者信息
Lipoldová M, Holán V
机构信息
Institute of Molecular Genetics, Czechoslovak Academy of Sciences, Prague.
出版信息
Immunology. 1990 May;70(1):136-7.
Abstract
Spleen cells from newborn mice are immunologically non-reactive and do not respond by proliferation to T- or B-cell mitogens. However, they synthesize significant levels of mRNA for interleukin-1 alpha (IL-1 alpha) and tumour necrosis factor-alpha (TNF-alpha) after mitogen stimulation. Since these two cytokines mediate many protective activities in the body, they may be important in ensuring the survival of immunologically immature newborns.
摘要
新生小鼠的脾细胞在免疫上无反应，对T细胞或B细胞促有丝分裂原不发生增殖反应。然而，在促有丝分裂原刺激后，它们能合成高水平的白细胞介素-1α（IL-1α）和肿瘤坏死因子-α（TNF-α）的mRNA。由于这两种细胞因子介导体内许多保护活性，它们可能在确保免疫未成熟的新生儿存活方面很重要。
Zotero 插件