Arf 样小 GTP 酶在纤毛和纤毛病中的分子观。
Molecular views of Arf-like small GTPases in cilia and ciliopathies.
机构信息
Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA.
出版信息
Exp Cell Res. 2013 Sep 10;319(15):2316-22. doi: 10.1016/j.yexcr.2013.03.024. Epub 2013 Mar 31.
Abstract
The primary cilia are microtubule-based organelles that protrude from most of the eukaryotic cells. Recognized as the cell's antenna, primary cilium functions as a signaling hub for many physiologically and developmentally important signaling cascades. Ciliary dysfunction causes a wide spectrum of syndromic human genetic diseases collectively termed "ciliopathies". Mounting evidences have shown that various small GTPases have been implicated in the context of cilia as well as human ciliopathies. However, how these small GTPases affect cilia formation and function remains poorly understood. Here we review and discuss the ciliary role of three Arf-like small GTPases (Arls), Arl3, Arl6, and Arl13b.
摘要
原发性纤毛是由微管组成的细胞器，从大多数真核细胞中伸出。被认为是细胞的天线，原发性纤毛作为许多生理和发育重要信号级联反应的信号枢纽。纤毛功能障碍导致广泛的综合征性人类遗传疾病，统称为“纤毛病”。越来越多的证据表明，各种小 GTPases 在纤毛以及人类纤毛病中都有涉及。然而，这些小 GTPases 如何影响纤毛的形成和功能仍知之甚少。在这里，我们回顾和讨论了三种 Arf 样小 GTPases（Arls）、Arl3、Arl6 和 Arl13b 的纤毛作用。
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3
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