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挪威前庭神经鞘瘤患者的工作残疾:眩晕预示着未来的依赖。

Working disability in Norwegian patients with vestibular schwannoma: vertigo predicts future dependence.

机构信息

Department of Neurosurgery, Haukeland University Hospital, Bergen, Norway.

出版信息

World Neurosurg. 2013 Dec;80(6):e301-5. doi: 10.1016/j.wneu.2013.03.069. Epub 2013 Mar 30.

Abstract

OBJECTIVE

We examined whether reduced hearing, tinnitus, dizziness, and unsteadiness affected the patients' ability to maintain work within a time frame of 2-10 years after diagnosis.

METHODS

A total of 434 consecutive patients were followed at regular intervals. Data on symptoms were scored prospectively and dichotomized by visual analog scales for tinnitus and vertigo. Study design is retrospective. Hearing acuity was scored according to the Gardner-Robertson scale, and unsteadiness was measured on a balance platform. Patients were asked about working status, and scored as receiving governmental compensation for disability.

RESULTS

Two hundred six patients were eligible for study. Of these, one died and nine were lost to follow-up. Ninety-seven patients received conservative management, 49 patients recieved gamma knife radiosurgery, and 50 patients were treated by microsurgery. Mean follow-up time was 58.7 months (range, 20-132 months). There was a significant increase in the number of individuals receiving compensation during the study period (P < 0.0001). At baseline, the proportion of pension receivers was within same range as that of the age- and sex-matched Norwegian population (5.61% vs. 6.91%; case-control odds ratio, 0.82; 95% confidence interval 0.45-1.49; P = 0.51, not significant). At the final time point, the increase in the number of receivers deviated significantly from the reference population (case-control odds ratio, 3.80; 95% confidence interval 2.71-5.33; P ≤ 0.001). Examining symptoms at first presentation as predictors of future dependence revealed that vertigo and higher mean age were associated with a higher risk (P < 0.001 and P = 0.015, respectively). No other symptoms were predictive of dependence.

CONCLUSIONS

In a prospectively followed cohort of Norwegian patients with vestibular schwannoma, vestibular complaints were significant predictors for becoming dependant of disability pension.

摘要

目的

我们研究了听力下降、耳鸣、头晕和不稳定是否会影响患者在诊断后 2-10 年内维持工作的能力。

方法

共对 434 例连续患者进行了定期随访。前瞻性地对症状数据进行评分,并通过耳鸣和眩晕的视觉模拟量表将其分为二分类。研究设计为回顾性。听力锐度根据 Gardner-Robertson 量表评分,不稳定性在平衡平台上测量。询问患者的工作状态,并根据残疾情况获得政府补偿进行评分。

结果

206 例患者符合研究条件。其中,1 例死亡,9 例失访。97 例患者接受保守治疗,49 例患者接受伽玛刀放射外科治疗,50 例患者接受显微镜手术治疗。平均随访时间为 58.7 个月(范围为 20-132 个月)。在研究期间,接受补偿的人数显著增加(P < 0.0001)。基线时,领取养老金者的比例与年龄和性别匹配的挪威人群相当(5.61%比 6.91%;病例对照优势比,0.82;95%置信区间 0.45-1.49;P = 0.51,无显著性)。在最后时间点,领取人数的增加明显偏离参考人群(病例对照优势比,3.80;95%置信区间 2.71-5.33;P ≤ 0.001)。检查首次出现时的症状作为未来依赖的预测因子表明,眩晕和较高的平均年龄与更高的风险相关(P < 0.001 和 P = 0.015)。没有其他症状可预测依赖。

结论

在挪威前庭神经鞘瘤前瞻性随访队列中,前庭主诉是残疾养老金依赖的重要预测因素。

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