Li Xiao-Dong, Ji Mei, Wu Jun, Jiang Jing-Ting, Wu Chang-Ping
Department of Oncology, Third Affiliated Hospital of Soochow University, Changzhou 213003, China.
Tumori. 2013 Jan-Feb;99(1):88-92. doi: 10.1177/030089161309900115.
We designed the present study to observe CD44s and CD44v6 expressions in colorectal cancer and evaluate their clinical value.
CD44s and CD44v6 expression in colorectal cancer tissues were examined by an immunohistochemical test. Survival analysis was performed with the Kaplan-Meier method, and the differences between the CD44-positive and -negative groups were evaluated with the logrank test.
The positive rates of CD44s and CD44v6 were 66.7% and 63.2%, respectively. There were significant associations between CD44s positive expression and Dukes' stage or tumor differentiation. There were significant associations between CD44v6 positive expression and tumor differentiation, Dukes' stage and lymph node metastasis. There was a significant difference in the 5-year survival rates between CD44v6-positive and CD44v6-negative groups (52.78% and 80.95%, respectively), but not between CD44s-positive and CD44s-negative groups (55.26% and 78.95%, respectively). Multivariate analysis indicated that CD44v6 positive expression predicts a poor prognosis.
CD44s and CD44v6 play important roles in the infiltration and metastasis of colorectal cancer. CD44v6 positive expression can be a predictor for a poor prognosis.
我们开展本研究以观察结直肠癌中CD44s和CD44v6的表达情况，并评估其临床价值。
采用免疫组织化学检测法检测结直肠癌组织中CD44s和CD44v6的表达。采用Kaplan-Meier法进行生存分析，并用对数秩检验评估CD44阳性组和阴性组之间的差异。
CD44s和CD44v6的阳性率分别为66.7%和63.2%。CD44s阳性表达与Dukes分期或肿瘤分化之间存在显著关联。CD44v6阳性表达与肿瘤分化、Dukes分期及淋巴结转移之间存在显著关联。CD44v6阳性组和阴性组的5年生存率存在显著差异（分别为52.78%和80.95%），但CD44s阳性组和阴性组之间无显著差异（分别为55.26%和78.95%）。多因素分析表明，CD44v6阳性表达预示预后不良。
CD44s和CD44v6在结直肠癌的浸润和转移中起重要作用。CD44v6阳性表达可作为预后不良的预测指标。
