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原始神经外胚层肿瘤(PNET)作为一种源自性腺外生殖细胞肿瘤的体细胞型恶性肿瘤:1例病例的临床、病理及分子特征

Primitive neuroectodermal tumor (PNET) as somatic-type malignancy arising from an extragonadal germ-cell tumor: clinical, pathological and molecular features of a case.

作者信息

Garg Amit, Nahal Ayoub, Turcotte Robert, Tabah Roger, Alcindor Thierry

机构信息

Department of Oncology, McGill University, Montreal, Quebec, Canada.

出版信息

Tumori. 2013 Jan-Feb;99(1):e24-7. doi: 10.1177/030089161309900128.

DOI:10.1177/030089161309900128
PMID:23549017
Abstract

We report a rare case of a 34-year-old man with a right axillary mass. Ten years previously, he had been diagnosed with a right scapular nonseminomatous germ-cell tumor consisting of teratoma, completely resected without any further treatment. Presently he was found to have a metastatic malignant small round cell tumor consistent with a secondary somatic malignancy arising in the background of nonseminomatous germ-cell tumor, teratoma, yolk sac tumor, and primitive neuroectodermal tumor with distinct chromosome 22 translocation. Although the patient initially responded well to chemotherapy with etoposide, cisplatin, ifosfamide and mesna, he relapsed shortly after.

摘要

我们报告了一例罕见的34岁男性右腋窝肿块病例。十年前,他被诊断出患有右肩胛骨非精原性生殖细胞肿瘤,由畸胎瘤组成,已完全切除,未进行任何进一步治疗。目前发现他患有转移性恶性小圆细胞瘤,与非精原性生殖细胞肿瘤、畸胎瘤、卵黄囊瘤和具有明显22号染色体易位的原始神经外胚层肿瘤背景下发生的继发性体细胞恶性肿瘤一致。尽管患者最初对依托泊苷、顺铂、异环磷酰胺和美司钠化疗反应良好,但不久后复发。

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