Tigges M, Tigges J, Fernandes A, Eggers H M, Gammon J A
Department of Anatomy, Emory University, Atlanta, Georgia.
Invest Ophthalmol Vis Sci. 1990 Jun;31(6):1035-46.
The influence of anomalous visual experience on the postnatal regulation of axial eye elongation was explored by raising newborn rhesus monkeys under different types of monocular and binocular deprivation and comparing their eye growth pattern with that of age-matched normal monkeys. Monocular manipulations included eyelid suture to eliminate pattern vision; continuous occlusion with an opaque lens to prevent visual experience; surgical removal of the natural lens to induce continuous blur; and correction of surgically induced aphakia with extended-wear contact lenses (EWCLs) to provide a focused image of near objects. Binocular manipulations involved correction of aphakia with an EWCL in one eye and continuous or partial occlusion of the phakic fellow eye. After monocular eyelid suture or occlusion, the deprived eyes were longer than the unmanipulated fellow eyes. Aphakic eyes, however, were shorter than their unmanipulated fellow eyes. The unmanipulated eyes followed the eye elongation pattern of age-matched normal monkeys. Binocular manipulations also resulted in differences in axial length between the two eyes. Aphakic eyes were shorter, and continuously occluded eyes were longer, than eyes of age-matched controls. After partial occlusion, however, the axial length of occluded eyes was similar to that of normal eyes. The finding that lid-sutured and occluded eyes become longer while aphakic eyes remain shorter than normal eyes suggests that additional factors besides retinal image quality control postnatal eye growth.
通过将新生恒河猴饲养在不同类型的单眼和双眼剥夺条件下，并将它们的眼睛生长模式与年龄匹配的正常猴子进行比较，探讨了异常视觉经验对出生后眼轴伸长调节的影响。单眼操作包括缝合眼睑以消除模式视觉；用不透明晶状体持续遮挡以防止视觉经验；手术摘除天然晶状体以诱导持续模糊；以及用长戴型隐形眼镜（EWCL）矫正手术引起的无晶状体状态以提供近物的聚焦图像。双眼操作包括用EWCL矫正一只眼睛的无晶状体状态，并对有晶状体的另一只眼睛进行持续或部分遮挡。单眼眼睑缝合或遮挡后，被剥夺的眼睛比未处理的对侧眼睛长。然而，无晶状体眼比未处理的对侧眼睛短。未处理的眼睛遵循年龄匹配的正常猴子的眼轴伸长模式。双眼操作也导致两只眼睛之间的眼轴长度差异。与年龄匹配的对照组相比，无晶状体眼较短，持续遮挡的眼睛较长。然而，部分遮挡后，被遮挡眼睛的眼轴长度与正常眼睛相似。眼睑缝合和遮挡的眼睛变长而无晶状体眼仍比正常眼睛短这一发现表明，除了视网膜图像质量外，还有其他因素控制出生后的眼睛生长。
