Elwell M R, Sammons M L, Liu C T, Beisel W R
Infect Immun. 1975 Apr;11(4):724-6. doi: 10.1128/iai.11.4.724-726.1975.
Acid-base alterations in Streptococcus pneumoniae infection were studied in 80 male albino rats. Hematocrit and concentrations of plasma electrolytes, glucose, and total protein were also measured. At 3-h intervals throughout a 27-h study, four control and four infected rats were anesthetized with ether, and blood samples were taken. Arterial blood pH, Po2, and hematocrit increased in the infected group, whereas arterial Pco2, HCO3-, and venous Po2 decreased. Plasma K+ concentration increased slightly and glucose levels decreased in the infected rats as the sepsis progressed. No significant changes were observed in venous blood pH, HCO3-, and Pco2. Plasma Na+, Cl-, and total protein remained unchanged. The increase in arterial blood pH and decrease in arterial Pco2 and HCO3- indicated respiratory alkalosis, which was present in rats infected with S. pneumoniae.
在80只雄性白化大鼠中研究了肺炎链球菌感染时的酸碱改变情况。还测量了血细胞比容以及血浆电解质、葡萄糖和总蛋白的浓度。在一项为期27小时的研究中，每隔3小时，用乙醚麻醉4只对照大鼠和4只感染大鼠，并采集血样。感染组动脉血pH、氧分压（Po2）和血细胞比容升高，而动脉二氧化碳分压（Pco2）、碳酸氢根（HCO3-）和静脉氧分压降低。随着脓毒症进展，感染大鼠的血浆钾（K+）浓度略有升高，葡萄糖水平降低。静脉血pH、HCO3-和Pco2未观察到显著变化。血浆钠（Na+）、氯（Cl-）和总蛋白保持不变。动脉血pH升高、动脉Pco2和HCO3-降低表明存在呼吸性碱中毒，这种情况存在于感染肺炎链球菌的大鼠中。
