The binding of the retro-analogue of glutathione disulfide to glutathione reductase.
作者信息
Janes W, Schulz G E
机构信息
Institut für Organische Chemie und Biochemie, Universität Freiburg, Federal Republic of Germany.
出版信息
J Biol Chem. 1990 Jun 25;265(18):10443-5. doi: 10.2210/pdb4gr1/pdb.
PMID:2355009
Abstract
The retro-analogue of glutathione disulfide was bound to the GSSG binding site of crystalline glutathione reductase. The binding mode revealed why the analogue is a very poor substrate in enzyme catalysis. The observed binding mode difference between natural substrate and retro-analogue is explained.
摘要
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