Bello S, Fanizzi R, Bonali C, Serafino L, Terlizzi N, Lapadula G
Rheumatology Unit, Medical School, University of Bari, Bari, Italy.
Reumatismo. 2013 Mar 28;65(1):40-5. doi: 10.4081/reumatismo.2013.40.
The so-called papular-purpuric gloves and socks syndrome (PPGSS) is a condition characterized by acute onset of intense erythema, edema and petechiae with a typical localization on the hands and feet, besides mucosal lesions of the oral cavity. The syndrome has a favorable and self-limited course, requiring only a symptomatic therapy. In the 50% of the cases described in literature (ninety cases in 22 years), is documented an acute infection caused by parvovirus B19 and in only two cases the onset of PPGSS is reported among different members of the same family. The aim of the work is to describe two cases of PPGSS arisen during a short time period in two family members affected by an acute parvovirus B19 infection found by serum sampling. The peculiarity of the study was the infrequence of the syndrome and the rareness of the description of PPGSS in rheumatology. This syndrome is usually described in dermatology, but it is also interesting for the rheumatologist because it comes in differential diagnosis with various autoimmune diseases.
所谓的丘疹紫癜性手套和袜子综合征（PPGSS）是一种以急性起病、强烈红斑、水肿和瘀点为特征的疾病，典型地局限于手足部位，此外还有口腔黏膜病变。该综合征病程良好且自限性，仅需对症治疗。在文献报道的病例中（22年90例），50%记录有由细小病毒B19引起的急性感染，且仅2例报道了在同一家族的不同成员中发生PPGSS。这项工作的目的是描述两例PPGSS病例，这两例病例在短时间内出现在两名受急性细小病毒B19感染的家庭成员中，该感染通过血清采样发现。该研究的独特之处在于该综合征的罕见性以及在风湿病学中对PPGSS描述的稀少。这种综合征通常在皮肤病学中描述，但对风湿病学家也很有意义，因为它参与多种自身免疫性疾病的鉴别诊断。
