Department of Biology, California Institute of Technology, Pasadena, CA 91125, USA.
Immunol Rev. 2013 May;253(1):129-45. doi: 10.1111/imr.12043.
Yin and Yang are two complementary forces that together describe the nature of real-world elements. Yin is the dark side; Yang is the light side. We describe microRNAs having both Yin and Yang characteristics because they can contribute to normal function (Yang) but also to autoimmunity, myeloproliferation, and cancer (Yin). We have been working on a number of microRNAs that have these dual characteristics and here we focus on two, miR-125b and miR-146a. We have concentrated on these two RNAs because we have very extensive knowledge of them, much of it from our laboratory, and also because they provide a strong contrast: the effects of overexpression of miR-125b are rapid, suggesting that it acts directly, whereas the effects of miR-146a are slow to develop, suggesting that they arise from chronic alterations in cellular behavior.
阴阳是描述现实世界元素本质的两种互补力量。阴是暗面；阳是亮面。我们描述具有阴阳特征的 microRNAs，因为它们既能促进正常功能（阳），也能导致自身免疫、骨髓增生和癌症（阴）。我们一直在研究许多具有这种双重特征的 microRNAs，这里我们重点关注两个，miR-125b 和 miR-146a。我们专注于这两个 RNA，是因为我们对它们有非常广泛的了解，其中大部分来自我们的实验室，还因为它们提供了一个强烈的对比：miR-125b 过表达的效果是迅速的，这表明它是直接作用的，而 miR-146a 的效果是缓慢发展的，这表明它们来自于细胞行为的慢性改变。
