miRNAs 的阴阳两面：白血病与免疫
The Yin and Yang of microRNAs: leukemia and immunity.
机构信息
Department of Biology, California Institute of Technology, Pasadena, CA 91125, USA.
出版信息
Immunol Rev. 2013 May;253(1):129-45. doi: 10.1111/imr.12043.
Abstract
Yin and Yang are two complementary forces that together describe the nature of real-world elements. Yin is the dark side; Yang is the light side. We describe microRNAs having both Yin and Yang characteristics because they can contribute to normal function (Yang) but also to autoimmunity, myeloproliferation, and cancer (Yin). We have been working on a number of microRNAs that have these dual characteristics and here we focus on two, miR-125b and miR-146a. We have concentrated on these two RNAs because we have very extensive knowledge of them, much of it from our laboratory, and also because they provide a strong contrast: the effects of overexpression of miR-125b are rapid, suggesting that it acts directly, whereas the effects of miR-146a are slow to develop, suggesting that they arise from chronic alterations in cellular behavior.
摘要
阴阳是描述现实世界元素本质的两种互补力量。阴是暗面；阳是亮面。我们描述具有阴阳特征的 microRNAs，因为它们既能促进正常功能（阳），也能导致自身免疫、骨髓增生和癌症（阴）。我们一直在研究许多具有这种双重特征的 microRNAs，这里我们重点关注两个，miR-125b 和 miR-146a。我们专注于这两个 RNA，是因为我们对它们有非常广泛的了解，其中大部分来自我们的实验室，还因为它们提供了一个强烈的对比：miR-125b 过表达的效果是迅速的，这表明它是直接作用的，而 miR-146a 的效果是缓慢发展的，这表明它们来自于细胞行为的慢性改变。
相似文献
1
The Yin and Yang of microRNAs: leukemia and immunity.miRNAs 的阴阳两面：白血病与免疫
Immunol Rev. 2013 May;253(1):129-45. doi: 10.1111/imr.12043.
2
Unique MicroRNAs Signature of Lymphocyte of Yang and Yin Syndromes in Acute Ischemic Stroke Patients.急性缺血性脑卒中患者阴阳证候淋巴细胞的独特 microRNAs 特征。
Chin J Integr Med. 2019 Aug;25(8):590-597. doi: 10.1007/s11655-018-2843-3. Epub 2018 Jun 20.
3
Yin-Yang: two sides of extracellular vesicles in inflammatory diseases.阴阳：细胞外囊泡在炎症性疾病中的两面性。
J Nanobiotechnology. 2024 Aug 27;22(1):514. doi: 10.1186/s12951-024-02779-9.
4
[Yin-yang relationship between oncogene and antioncogene].[癌基因与抗癌基因的阴阳关系]
Zhongguo Zhong Xi Yi Jie He Za Zhi. 2009 Jan;29(1):72-5.
5
MicroRNA-411-3p motivates methotrexate's cellular uptake and cytotoxicity via targeting Yin-yang 1 in leukemia cells.微小 RNA-411-3p 通过靶向白血病细胞中的 Yin-yang 1 促进甲氨蝶呤的细胞摄取和细胞毒性。
Acta Biochim Pol. 2023 Sep 19;70(3):721-727. doi: 10.18388/abp.2020_6242.
6
[Review on experimental studies on Yin-yang theory of traditional Chinese medicine].[中医阴阳学说的实验研究综述]
Zhonghua Yi Shi Za Zhi. 2005 Jan;35(1):22-4.
7
Homeostasis Research Model Based on Yin-Yang Theory: Five Examples.基于阴阳理论的体内平衡研究模型：五个实例。
Chin J Integr Med. 2021 Jun;27(6):403-407. doi: 10.1007/s11655-021-2861-4. Epub 2021 Jan 12.
8
The Yin-Yang Dynamics in Cancer Pharmacogenomics and Personalized Medicine.癌症药物基因组学和个性化医学中的阴阳动态。
Methods Mol Biol. 2022;2547:141-163. doi: 10.1007/978-1-0716-2573-6_6.
9
Yin-yang regulating effects of cancer-associated genes, proteins, and cells: An ancient Chinese concept in vogue in modern cancer research.癌症相关基因、蛋白质和细胞的阴阳调节作用：现代癌症研究中的一个古老的中国概念。
Biosci Trends. 2018 Jan 9;11(6):612-618. doi: 10.5582/bst.2017.01259. Epub 2017 Dec 14.
10
Novel pathways in the yin-yang of immunomodulation.免疫调节阴阳学说中的新途径。
Curr Opin Pharmacol. 2013 Aug;13(4):543-6. doi: 10.1016/j.coph.2013.06.010. Epub 2013 Jul 16.
引用本文的文献
1
The Importance of Selected Dysregulated microRNAs in Diagnosis and Prognosis of Childhood B-Cell Precursor Acute Lymphoblastic Leukemia.特定失调的微小RNA在儿童B细胞前体急性淋巴细胞白血病诊断和预后中的重要性
Cancers (Basel). 2023 Jan 9;15(2):428. doi: 10.3390/cancers15020428.
2
Paradoxical attenuation of neuroinflammatory response upon LPS challenge in miR-146b deficient mice.miR-146b 缺陷型小鼠在 LPS 刺激下神经炎症反应的矛盾性减弱。
Front Immunol. 2022 Oct 31;13:996415. doi: 10.3389/fimmu.2022.996415. eCollection 2022.
3
Human Melanoma Cells Differentially Express RNASEL/RNase-L and miR-146a-5p under Sex Hormonal Stimulation.在性激素刺激下，人黑色素瘤细胞中RNASEL/RNase-L和miR-146a-5p表达存在差异。
Curr Issues Mol Biol. 2022 Oct 11;44(10):4790-4802. doi: 10.3390/cimb44100326.
4
miR-1297 sensitizes glioma cells to temozolomide (TMZ) treatment through targeting adrenomedullin (ADM).miR-1297 通过靶向肾上腺髓质素 (ADM) 使神经胶质瘤细胞对替莫唑胺 (TMZ) 治疗敏感。
J Transl Med. 2022 Oct 1;20(1):443. doi: 10.1186/s12967-022-03647-6.
5
The Yin-Yang Dynamics in Cancer Pharmacogenomics and Personalized Medicine.癌症药物基因组学和个性化医学中的阴阳动态。
Methods Mol Biol. 2022;2547:141-163. doi: 10.1007/978-1-0716-2573-6_6.
6
Enhanced Cognition and Neurogenesis in miR-146b Deficient Mice.miR-146b 缺陷型小鼠的认知增强和神经发生。
Cells. 2022 Jun 22;11(13):2002. doi: 10.3390/cells11132002.
7
MiRNA-20b/SUFU/Wnt axis accelerates gastric cancer cell proliferation, migration and EMT.微小RNA-20b/抑癌蛋白/翼状螺旋转录因子轴促进胃癌细胞增殖、迁移及上皮-间质转化。
Heliyon. 2021 Apr 12;7(4):e06695. doi: 10.1016/j.heliyon.2021.e06695. eCollection 2021 Apr.
8
Transcriptomic Analysis Reveals Host miRNAs Correlated with Immune Gene Dysregulation during Fatal Disease Progression in the Ebola Virus Cynomolgus Macaque Disease Model.转录组分析揭示了在埃博拉病毒食蟹猴疾病模型致命疾病进展过程中与免疫基因失调相关的宿主微小RNA。
Microorganisms. 2021 Mar 23;9(3):665. doi: 10.3390/microorganisms9030665.
9
MicroRNAs Associated With a Good Prognosis of Acute Myeloid Leukemia and Their Effect on Macrophage Polarization.与急性髓系白血病预后良好相关的 microRNAs 及其对巨噬细胞极化的影响。
Front Immunol. 2021 Jan 15;11:582915. doi: 10.3389/fimmu.2020.582915. eCollection 2020.
10
Zhibaidihuang Decoction Ameliorates Cell Oxidative Stress by Regulating the Keap1-Nrf2-ARE Signalling Pathway.知柏地黄丸通过调节Keap1-Nrf2-ARE信号通路改善细胞氧化应激。
Evid Based Complement Alternat Med. 2020 Feb 12;2020:9294605. doi: 10.1155/2020/9294605. eCollection 2020.
本文引用的文献
1
Molecular pathophysiology of myelodysplastic syndromes.骨髓增生异常综合征的分子病理生理学。
Annu Rev Pathol. 2013 Jan 24;8:21-47. doi: 10.1146/annurev-pathol-011811-132436. Epub 2012 Aug 28.
2
miR-146a controls the resolution of T cell responses in mice.miR-146a 控制小鼠 T 细胞反应的消退。
J Exp Med. 2012 Aug 27;209(9):1655-70. doi: 10.1084/jem.20112218. Epub 2012 Aug 13.
3
Regulation of monocyte functional heterogeneity by miR-146a and Relb.miR-146a 和 Relb 调节单核细胞功能异质性。
Cell Rep. 2012 Apr 19;1(4):317-24. doi: 10.1016/j.celrep.2012.02.009.
4
B-cell regulator of immunoglobulin heavy-chain transcription (Bright)/ARID3a is a direct target of the oncomir microRNA-125b in progenitor B-cells.B 细胞免疫球蛋白重链转录调控因子（Bright）/ARID3a 是前体细胞 B 细胞中致癌 miRNA-125b 的直接靶标。
Leukemia. 2012 Oct;26(10):2224-32. doi: 10.1038/leu.2012.95. Epub 2012 Apr 3.
5
MicroRNAs, new effectors and regulators of NF-κB.微小 RNA，NF-κB 的新效应因子和调节因子。
Immunol Rev. 2012 Mar;246(1):205-20. doi: 10.1111/j.1600-065X.2011.01089.x.
6
Oncomir miR-125b regulates hematopoiesis by targeting the gene Lin28A.抑癌 miRNA-125b 通过靶向 Lin28A 基因调节造血。
Proc Natl Acad Sci U S A. 2012 Mar 13;109(11):4233-8. doi: 10.1073/pnas.1200677109. Epub 2012 Feb 24.
7
MicroRNAs and hematopoietic cell development.微小 RNA 与造血细胞发育。
Curr Top Dev Biol. 2012;99:145-74. doi: 10.1016/B978-0-12-387038-4.00006-9.
8
microRNA regulation of inflammatory responses.miRNA 对炎症反应的调控。
Annu Rev Immunol. 2012;30:295-312. doi: 10.1146/annurev-immunol-020711-075013. Epub 2012 Jan 3.
9
Genetic association of miRNA-146a with systemic lupus erythematosus in Europeans through decreased expression of the gene.通过降低基因表达，miRNA-146a 与欧洲人群的系统性红斑狼疮的遗传关联。
Genes Immun. 2012 Apr;13(3):268-74. doi: 10.1038/gene.2011.84. Epub 2012 Jan 5.
10
Genetic screen identifies microRNA cluster 99b/let-7e/125a as a regulator of primitive hematopoietic cells.遗传筛选确定 microRNA 簇 99b/let-7e/125a 为原始造血细胞的调节因子。
Blood. 2012 Jan 12;119(2):377-87. doi: 10.1182/blood-2011-01-331686. Epub 2011 Nov 28.
Zotero 插件