磷酸肌醇 3-激酶和 INPP4B 在人乳腺癌中的作用。
Phosphoinositide 3-kinase and INPP4B in human breast cancer.
机构信息
Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia.
出版信息
Ann N Y Acad Sci. 2013 Mar;1280:1-5. doi: 10.1111/nyas.12036.
PMID:23551093
Abstract
The PI3K/Akt signaling pathway is frequently increased in many human cancers, including breast cancer. Recent studies have identified INPP4B, which inhibits PI3K signaling, as an emerging tumor suppressor in breast cancer. This short review discusses these issues and the possibility that INPP4B is an important regulator in many cancers.
摘要
PI3K/Akt 信号通路在许多人类癌症中经常被激活，包括乳腺癌。最近的研究已经确定了 INPP4B，它抑制 PI3K 信号，作为乳腺癌中一种新的肿瘤抑制因子。这篇简短的综述讨论了这些问题以及 INPP4B 可能是许多癌症中的一个重要调节剂的可能性。
Zotero 插件