CuCl 催化带有特戊酰胺导向基团的芳烃和杂芳烃的邻位三氟甲基化反应。
CuCl-catalyzed ortho trifluoromethylation of arenes and heteroarenes with a pivalamido directing group.
机构信息
Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084, China.
出版信息
Chem Commun (Camb). 2013 May 18;49(40):4552-4. doi: 10.1039/c3cc41331d. Epub 2013 Apr 4.
PMID:23552192
Abstract
The CuCl catalyzed direct trifluoromethylation of sp(2) C-H bonds has been realized, using the Togni reagent as the CF3 source. This reaction achieves the goal of regio-selectively converting C-H into C-CF3 with ecological and readily available starting materials.
摘要
CuCl 催化的 sp(2) C-H 键的直接三氟甲基化已经实现，使用 Togni 试剂作为 CF3 源。该反应以生态友好和易得的起始原料实现了区域选择性地将 C-H 转化为 C-CF3 的目标。
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