1] Division of Urology, Department of Surgery, Far Eastern Memorial Hospital, Taipei, Taiwan [2] Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan [3] School of Health Care Administration, Taipei Medical University, Taipei, Taiwan.
Int J Impot Res. 2013 Nov-Dec;25(6):224-8. doi: 10.1038/ijir.2013.15. Epub 2013 Apr 4.
As bladder pain syndrome/interstitial cystitis (BPS/IC) has been demonstrated to proceed through the inflammatory pathways to cause endothelial dysfunction, and endothelial dysfunction is a major factor in the development of ED, it is possible that BPS/IC may be associated with ED. This study set out to investigate the putative association between ED and BPS/IC by using a population-based data set and case-control design in Taiwan. We obtained the data from Taiwan's National Health Insurance Research Database. Cases included 32,856 ED patients ≥ 18-years old and 164,280 matched controls. Conditional logistic regression analyses were performed to compare the odds ratios (OR) and corresponding 95% confidence intervals (CIs) of having been previously diagnosed with BPS/IC in cases and controls. Among the total sample of 197,136 subjects, the prevalence of prior BPS/IC was 0.05%. The prevalence of prior BPS/IC was 0.10% and 0.04% for cases and controls, respectively (P<0.001). Conditional logistic regression analysis revealed that when compared with controls, the OR of prior BPS/IC for cases was 1.75 (95% CI=1.12-2.71) after adjusting for monthly income, geographic location, hypertension, diabetes, coronary heart disease, hyperlipidemia, renal disease, obesity, depressive disorder, alcohol abuse/alcohol-dependence syndromes and the number of outpatient visits within 1 year before index date. Subjects aged between 18 and 39 were additionally found to have the highest ORs for prior BPS/IC among cases when compared with controls (OR=10.40; 95% CI=2.93-36.94). There was an association between BPS/IC and ED. The youngest cases with ED were found to have the strongest magnitudes of association with BPS/IC.
由于膀胱疼痛综合征/间质性膀胱炎 (BPS/IC) 已被证明通过炎症途径导致内皮功能障碍，而内皮功能障碍是 ED 发展的主要因素，因此 BPS/IC 可能与 ED 有关。本研究旨在通过使用基于人群的数据集和病例对照设计在台湾调查 ED 与 BPS/IC 之间的潜在关联。我们从台湾国家健康保险研究数据库中获取数据。病例包括 32856 名年龄≥18 岁的 ED 患者和 164280 名匹配对照。采用条件逻辑回归分析比较病例和对照中先前诊断为 BPS/IC 的比值比 (OR) 和相应的 95%置信区间 (CI)。在总共 197136 名受试者中，先前 BPS/IC 的患病率为 0.05%。病例和对照中先前 BPS/IC 的患病率分别为 0.10%和 0.04%（P<0.001）。条件逻辑回归分析显示，与对照组相比，在校正月收入、地理位置、高血压、糖尿病、冠心病、高脂血症、肾病、肥胖、抑郁障碍、酗酒/酒精依赖综合征和索引日期前 1 年内的门诊就诊次数后，病例中先前 BPS/IC 的 OR 为 1.75（95%CI=1.12-2.71）。还发现，与对照组相比，年龄在 18 至 39 岁之间的病例中先前 BPS/IC 的 OR 最高（OR=10.40；95%CI=2.93-36.94）。BPS/IC 与 ED 之间存在关联。发现患有 ED 的最年轻病例与 BPS/IC 的关联程度最强。
