Chen Ho-Mei, Lin Ching-Chun, Kang Chih-Sen, Lee Chun-Te, Lin Herng-Ching, Chung Shiu-Dong
Department of Internal Medicine, PoJen General Hospital, Taipei, Taiwan.
Neurourol Urodyn. 2014 Jun;33(5):511-5. doi: 10.1002/nau.22444. Epub 2013 Jun 27.
Vascular factor was proposed as being involved in the etiology of bladder pain syndrome/interstitial cystitis (BPS/IC). However, few studies have attempted to investigate the relationship between BPS/IC and cardiovascular disease. This study aimed to investigate the risk of coronary heart disease (CHD) among BPS/IC subjects during a 3-year follow-up period.
Data for this retrospective matched-cohort study were retrieved from the Taiwan "Longitudinal Health Insurance Database 2000." There were 752 BPS/IC female subjects in the study cohort and 3,760 randomly selected female subjects in the comparison cohort. We individually tracked each subject for 3 years and identified each subject that received a subsequent diagnosis of CHD during that follow-up period.
Results showed that incidence rates of CHD during the 3-year follow-up period were 19.50 (95% confidence interval (CI): 14.35-25.95) and 8.87 (95% CI: 7.25-10.74) per 1,000 person-years for the study and comparison cohorts, respectively. The Cox proportional hazards regression suggested that the hazard ratio for CHD in subjects with BPS/IC was 1.65 (95% CI: 1.09-2.48) within the 3-year follow-up period following the index date compared to the comparison subjects after adjusting for monthly income, geographic region, hypertension, diabetes, hyperlipidemia, chronic kidney disease, bladder outlet obstruction, urinary tract infection, chronic pelvic pain, overactive bladder, and number of physician visits during the 3-year follow up period.
Our study demonstrated an association between BPS/IC and a subsequent CHD diagnosis. We advise clinicians to screen subjects with BPS/IC for modifiable risk factors for CHD.
血管因素被认为与膀胱疼痛综合征/间质性膀胱炎（BPS/IC）的病因有关。然而，很少有研究试图探讨BPS/IC与心血管疾病之间的关系。本研究旨在调查BPS/IC患者在3年随访期内患冠心病（CHD）的风险。
本回顾性匹配队列研究的数据取自台湾“2000年纵向健康保险数据库”。研究队列中有752名BPS/IC女性患者，对照队列中有3760名随机选择的女性患者。我们对每个受试者进行了3年的跟踪，并确定了在该随访期内随后被诊断为CHD的每个受试者。
结果显示，研究队列和对照队列在3年随访期内冠心病的发病率分别为每1000人年19.50（95%置信区间（CI）：14.35 - 25.95）和8.87（95%CI：7.25 - 10.74）。Cox比例风险回归分析表明，在调整了月收入、地理区域、高血压、糖尿病、高脂血症、慢性肾脏病、膀胱出口梗阻、尿路感染、慢性盆腔疼痛、膀胱过度活动症以及3年随访期内的就诊次数后，与对照受试者相比，BPS/IC患者在索引日期后的3年随访期内患CHD的风险比为1.65（95%CI：1.09 - 2.）。
我们的研究表明BPS/IC与随后的CHD诊断之间存在关联。我们建议临床医生对BPS/IC患者筛查CHD的可改变风险因素。
