Chen Weidong, Zhao Hua, Li Tiegang, Yao Hongliang
Department of General Surgery, The Second Xiang-Ya Hospital, Central South University, ChangSha, Hunan, 410011, China.
Tumour Biol. 2013 Aug;34(4):2255-9. doi: 10.1007/s13277-013-0766-3. Epub 2013 Apr 4.
The HFE gene has been suggested to play an important role in the pathogenesis of colorectal cancer. However, the results have been conflicting. In this study, we performed a meta-analysis to clarify the association of HFE gene C282Y variant with colorectal cancer. PubMed and Embase were retrieved to identify the potential literature. Pooled odds ratio (OR) with 95 % confidence interval (CI) was calculated using fixed- or random-effects model. A total of eight papers including nine studies (7,588 colorectal cancer cases and 81,571 controls) for HFE gene C282Y variant were included in the meta-analysis. The result indicated that HFE gene C282Y variant was significantly associated with colorectal cancer under recessive model (OR = 2.00, 95 % CI = 1.32-3.04), with no evidence of between-study heterogeneity (I (2) = 0.2 %, p = 0.432). Further subgroup analysis by number of cases suggested the effect was significant in studies with more than 500 cases (OR = 2.51, 95 % CI = 1.58-3.98, I (2) = 0.0 %, p = 0.921), but not in studies with less than 500 cases (OR = 0.75, 95 % CI = 0.28-1.97, I (2) = 0.0 %, p = 0.622). The current meta-analysis supported the positive association of HFE gene C282Y variant with colorectal cancer. Further large-scale studies with the consideration for gene-gene/gene-environment interactions should be conducted to investigate the association.
HFE基因被认为在结直肠癌的发病机制中起重要作用。然而，研究结果相互矛盾。在本研究中，我们进行了一项荟萃分析，以阐明HFE基因C282Y变异与结直肠癌的关联。检索了PubMed和Embase以识别潜在文献。使用固定效应或随机效应模型计算合并比值比（OR）及95%置信区间（CI）。共有8篇论文纳入了HFE基因C282Y变异的9项研究（7588例结直肠癌病例和81571例对照）进行荟萃分析。结果表明，在隐性模型下，HFE基因C282Y变异与结直肠癌显著相关（OR = 2.00，95%CI = 1.32 - 3.04），且无研究间异质性证据（I² = 0.2%，p = 0.432）。按病例数进行的进一步亚组分析表明，在病例数超过500例的研究中效应显著（OR = 2.51，95%CI = 1.58 - 3.98，I² = 0.0%，p = 0.921），而在病例数少于500例的研究中不显著（OR = 0.75，95%CI = 0.28 - 1.97，I² = 0.0%，p = 0.622）。当前的荟萃分析支持HFE基因C282Y变异与结直肠癌呈正相关。应进行进一步考虑基因 - 基因/基因 - 环境相互作用的大规模研究以调查这种关联。
