Unit of Clinical Chemistry, Department of Medical Biosciences, Umeå University, Umeå, Sweden.
Dis Colon Rectum. 2012 Mar;55(3):337-44. doi: 10.1097/DCR.0b013e318241199e.
High iron levels can increase the formation of noxious oxygen radicals, which are thought to promote carcinogenesis.
The aim of this prospective study was to determine whether iron biomarkers and HFE genotypes, which influence iron regulation, constitute risk factors for colorectal cancer.
This is a prospective nested case-referent study.
The study was performed within the population-based Northern Sweden Health and Disease Study.
The study included 226 cases of colorectal cancer and 437 matched referents.
Conditional regression analysis was performed. Adjustments for smoking, smoking and BMI, and HFE C282Y and H63D were performed.
The highest quintile of total iron-binding capacity showed significantly higher risk for colorectal cancer, unadjusted OR 2.35 (95% CI 1.38-4.02). When stratified by sex, the findings were only present in women (OR 3.34 (95% CI 1.59-7.02)). Ferritin was associated with reduced risk throughout quintiles 2 to 5 both in univariate and multivariate models.
Colorectal cancer may influence iron markers because of occult bleeding. Homozygotes for HFE C282Y were too few to make conclusions for this group. The relatively short follow-up time might be insufficient to detect risk of iron biomarkers.
High iron levels do not increase the risk of colorectal cancer. HFE genotypes influencing iron uptake had no effect on colorectal cancer risk.
高铁水平可能会增加有害氧自由基的形成，而这些自由基被认为会促进癌症的发生。
本前瞻性研究旨在确定影响铁调节的铁生物标志物和 HFE 基因型是否构成结直肠癌的风险因素。
这是一项前瞻性嵌套病例对照研究。
该研究在基于人群的瑞典北部健康与疾病研究中进行。
该研究包括 226 例结直肠癌患者和 437 名匹配的对照者。
采用条件回归分析。进行了吸烟、吸烟和 BMI 以及 HFE C282Y 和 H63D 的调整。
总铁结合能力最高的五分位数显示结直肠癌的风险显著增加，未经调整的 OR 为 2.35（95%CI 1.38-4.02）。按性别分层后，仅在女性中发现（OR 3.34（95%CI 1.59-7.02））。在单变量和多变量模型中，铁蛋白在 2 至 5 分位数均与风险降低相关。
由于隐匿性出血，结直肠癌可能会影响铁标志物。HFE C282Y 纯合子的数量太少，无法对该组做出结论。相对较短的随访时间可能不足以检测铁生物标志物的风险。
高铁水平不会增加结直肠癌的风险。影响铁摄取的 HFE 基因型对结直肠癌风险没有影响。
