Freton Maxime, Lemogne Cédric, Bergouignan Loretxu, Delaveau Pauline, Lehéricy Stéphane, Fossati Philippe
Faculté de Médecine, Université Pierre et Marie Curie (UPMC), Paris, France,
Brain Struct Funct. 2014 May;219(3):959-68. doi: 10.1007/s00429-013-0546-2. Epub 2013 Apr 4.
Visual perspective (i.e. first-person versus third-person perspective) during autobiographical memory (AM) retrieval plays a role in both emotional regulation and self-related processes. However, its neural underpinnings remain mostly unexplored. Visual perspective during AM retrieval was assessed in two independent datasets of 45 and 20 healthy young adults with two different AM retrieval tasks. Diffeomorphic anatomical registration using exponentiated lie algebra and voxel-based morphometry were used to assess individual differences in the precuneus grey matter volume. The spontaneous tendency to recall memories from a first-person perspective was positively correlated with the right precuneus volume among the two independent datasets. Whole-brain analyses revealed that these results were relatively specific to the anterior part of the right precuneus. Our results provide first evidence for the role of the precuneus in egocentric spatial processing in the context of AM retrieval among healthy subjects.
自传体记忆（AM）检索过程中的视觉视角（即第一人称视角与第三人称视角）在情绪调节和自我相关过程中均发挥作用。然而，其神经基础大多仍未被探索。在两个分别包含45名和20名健康年轻成年人的独立数据集中，通过两项不同的AM检索任务对AM检索过程中的视觉视角进行了评估。使用基于指数李代数的微分同胚解剖配准和基于体素的形态计量学来评估楔前叶灰质体积的个体差异。在这两个独立数据集中，从第一人称视角回忆记忆的自发倾向与右侧楔前叶体积呈正相关。全脑分析表明，这些结果相对特定于右侧楔前叶的前部。我们的结果首次证明了楔前叶在健康受试者AM检索背景下的自我中心空间处理中的作用。
