手性树枝状膦氧氮杂环戊烷铱配合物催化的 2,4-二芳基-1,5-苯并二氮杂卓的高对映选择性氢化反应。
Highly enantioselective hydrogenation of 2,4-diaryl-1,5-benzodiazepines catalyzed by dendritic phosphinooxazoline iridium complexes.
机构信息
Beijing National Laboratory for Molecular Sciences and CAS, Institute of Chemistry and Graduate School, Chinese Academy of Sciences (CAS), Beijing 100190, PR China.
出版信息
Chem Asian J. 2013 Jun;8(6):1101-4. doi: 10.1002/asia.201300150. Epub 2013 Mar 28.
A PHOX with arms: A series of dendrimers with Ir phosphinooxazoline (PHOX) cores were designed and synthesized and found to be highly effective and recoverable catalysts for asymmetric hydrogenation of 2,4-diaryl-1,5-benzodiazepines. An obvious positive dendritic effect on reactivity was observed, leading to chiral nitrogen-containing heterocycles with excellent enantioselectivities.
含臂型树状大分子的手性磷氮配体
设计并合成了一系列以 Ir 膦氧氮杂环卡宾（PHOX）为核的树状大分子配体，发现它们是高效和可回收的催化剂，可用于 2,4-二芳基-1,5-苯并二氮杂*的不对称氢化反应。反应活性表现出明显的正树枝状效应，得到的手性含氮杂环具有优异的对映选择性。
苯并二氮杂（benzodiazepine）是一种精神科药物，俗称“安定”，是一种镇静剂，属于苯二氮䓬类药物。
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