以铱（联萘酚）为核的树枝状大分子催化喹啉的对映选择性氢化反应：催化活性的显著提高。

Enantioselective hydrogenation of quinolines catalyzed by Ir(BINAP)-cored dendrimers: dramatic enhancement of catalytic activity.

作者信息

Wang Zhi-Jian, Deng Guo-Jun, Li Yong, He Yan-Mei, Tang Wei-Jun, Fan Qing-Hua

机构信息

Beijing National Laboratory for Molecular Sciences, Center for Chemical Biology, Institute of Chemistry, Chinese Academy of Sciences, Beijing, China.

出版信息

Org Lett. 2007 Mar 29;9(7):1243-6. doi: 10.1021/ol0631410. Epub 2007 Mar 1.

DOI:10.1021/ol0631410

PMID:17328554

Abstract

[structure: see text]. The asymmetric hydrogenation of quinolines catalyzed by chiral dendritic catalysts derived from BINAP gave the corresponding products with high enantioselectivities (up to 93%), excellent catalytic activities (TOF up to 3450 h(-1)), and productivities (TON up to 43,000). In addition, the third-generation catalyst could be recovered by precipitation and filtration and reused at least six times with similar enantioselectivity.

摘要

[结构：见原文]。由联萘酚（BINAP）衍生的手性树枝状催化剂催化喹啉的不对称氢化反应，得到了相应的产物，其对映选择性高（高达93%）、催化活性优异（TOF高达3450 h⁻¹）且产率高（TON高达43000）。此外，第三代催化剂可通过沉淀和过滤回收，并至少重复使用六次，且对映选择性相似。