Hematopoietic stem cells and HIV infection.
作者信息
Pace Matthew, O'Doherty Una
出版信息
J Infect Dis. 2013 Jun 15;207(12):1790-2. doi: 10.1093/infdis/jit120. Epub 2013 Apr 3.
Abstract
摘要
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Hematopoietic stem cells and HIV infection.造血干细胞与HIV感染。
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本文引用的文献
1
CD133+ hematopoietic progenitor cells harbor HIV genomes in a subset of optimally treated people with long-term viral suppression.在经过最佳治疗且长期病毒抑制的人群中，一部分 CD133+ 造血祖细胞中携带 HIV 基因组。
J Infect Dis. 2013 Jun 15;207(12):1807-16. doi: 10.1093/infdis/jit118. Epub 2013 Apr 3.
2
Hematopoietic precursor cells isolated from patients on long-term suppressive HIV therapy did not contain HIV-1 DNA.从长期接受抑制性 HIV 治疗的患者中分离出的造血前体细胞不含 HIV-1 DNA。
J Infect Dis. 2012 Jul 1;206(1):28-34. doi: 10.1093/infdis/jis301. Epub 2012 Apr 25.
3
Integrated HIV DNA accumulates prior to treatment while episomal HIV DNA records ongoing transmission afterwards.整合的 HIV 病毒 DNA 会在治疗前积累，而游离的 HIV 病毒 DNA 则记录着治疗后的持续传播。
AIDS. 2012 Mar 13;26(5):543-50. doi: 10.1097/QAD.0b013e328350fb3c.
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HIV-1 DNA is detected in bone marrow populations containing CD4+ T cells but is not found in purified CD34+ hematopoietic progenitor cells in most patients on antiretroviral therapy.在接受抗逆转录病毒治疗的大多数患者中，骨髓中含有 CD4+ T 细胞的群体可检测到 HIV-1 DNA，但在纯化的 CD34+ 造血祖细胞中未发现 HIV-1 DNA。
J Infect Dis. 2012 Mar 15;205(6):1014-8. doi: 10.1093/infdis/jir884. Epub 2012 Jan 24.
5
Isolation of single human hematopoietic stem cells capable of long-term multilineage engraftment.分离能够长期多谱系植入的单个人类造血干细胞。
Science. 2011 Jul 8;333(6039):218-21. doi: 10.1126/science.1201219.
6
HIV-1 utilizes the CXCR4 chemokine receptor to infect multipotent hematopoietic stem and progenitor cells.HIV-1 利用 CXCR4 趋化因子受体感染多能造血干细胞和祖细胞。
Cell Host Microbe. 2011 Mar 17;9(3):223-234. doi: 10.1016/j.chom.2011.02.005.
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Hematopoietic stem/precursor cells as HIV reservoirs.造血干细胞/祖细胞作为 HIV 的储存库。
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HIV-1 infects multipotent progenitor cells causing cell death and establishing latent cellular reservoirs.HIV-1 感染多能祖细胞，导致细胞死亡并建立潜伏的细胞储库。
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