Tobise K, Haneda T, Onodera S
First Department of Internal Medicine, Asahikawa Medical College, Japan.
Jpn Circ J. 1990 Feb;54(2):175-82. doi: 10.1253/jcj.54.175.
In order to evaluate whether there is pulmonary vascular disease in patients with atrial septal defect (ASD), we used the pulmonary vascular input impedance to estimate the stiffness of the pulmonary vessels with before and after surgical intervention. Ten control subjects and 11 patients with ASD (9 operable and 2 inoperable) were examined. In preoperative patients the decreased total pulmonary resistance (Rin) and pulmonary vascular resistance appeared to open new parallel vascular channels with increased blood flow. Further, there were no significant differences in the pulmonary vascular input impedance spectrum and phase, and characteristic impedance among control subjects, preoperative and postoperative patients. Although distensibility of the pulmonary vascular wall in operable patients was similar to that in control subjects, an excessive elevation in Rin and input impedance modulus was observed in inoperable patients. The results demonstrate that the normal input impedance spectrum and phase in patients with ASD is predictive of a good prognosis after successful surgical correction.
为了评估房间隔缺损（ASD）患者是否存在肺血管疾病，我们使用肺血管输入阻抗来估计手术干预前后肺血管的僵硬度。对10名对照受试者和11例ASD患者（9例可手术，2例不可手术）进行了检查。术前患者总肺阻力（Rin）降低，肺血管阻力似乎打开了新的平行血管通道，血流量增加。此外，对照受试者、术前和术后患者的肺血管输入阻抗频谱、相位以及特性阻抗之间均无显著差异。虽然可手术患者的肺血管壁扩张性与对照受试者相似，但不可手术患者的Rin和输入阻抗模量过度升高。结果表明，ASD患者正常的输入阻抗频谱和相位预示着成功手术矫正后预后良好。
