Department of Bioengineering, University of Colorado at Denver Anschutz Medical Campus (UCD-AMC), Aurora, Colorado, USA.
Compr Physiol. 2011 Jul;1(3):1413-35. doi: 10.1002/cphy.c100005.
This article introduces the concept of pulmonary vascular stiffness, discusses its increasingly recognized importance as a diagnostic marker in the evaluation of pulmonary vascular disease, and describes methods to measure and model it clinically, experimentally, and computationally. It begins with a description of systems-level methods to evaluate pulmonary vascular compliance and recent clinical efforts in applying such techniques to better predict patient outcomes in pulmonary arterial hypertension. It then progresses from the systems-level to the local level, discusses proposed methods by which upstream pulmonary vessels increase in stiffness, introduces concepts around vascular mechanics, and concludes by describing recent work incorporating advanced numerical methods to more thoroughly evaluate changes in local mechanical properties of pulmonary arteries.
本文介绍了肺血管僵硬的概念，讨论了其作为肺血管疾病评估的诊断标志物的重要性日益增加，并描述了临床上、实验中和计算上测量和建模的方法。本文首先描述了评估肺血管顺应性的系统方法，以及最近在应用这些技术来更好地预测肺动脉高压患者预后方面的临床努力。然后，本文从系统水平到局部水平进行讨论，讨论了上游肺血管僵硬度增加的方法，介绍了血管力学方面的概念，并以描述最近结合先进数值方法更全面地评估肺动脉局部力学特性变化的工作结束。
