Department of Endocrinology and Applied Medical Science, Tohoku University Graduate School of Medicine, Sendai, Japan.
Acta Histochem Cytochem. 2013 Feb 28;46(1):47-50. doi: 10.1267/ahc.12030. Epub 2013 Feb 13.
Expression of (pro)renin receptor ((P)RR), a specific receptor for renin and prorenin, was studied in rat pituitary gland. In situ hybridization showed that cells expressing (P)RR mRNA were widely distributed in the anterior lobe and intermediate lobe of the pituitary gland. Double-staining using in situ hybridization for (P)RR mRNA and immunohistochemistry for the pituitary hormones showed that (P)RR mRNA was expressed in most of the GH cells and ACTH cells in the anterior lobe. (P)RR mRNA was also expressed in a few prolactin cells and TSH cells, but not in LH cells. The present study has shown for the first time the distribution of (P)RR mRNA expressing cells in the rat pituitary gland. These findings suggest that (P)RR plays physiological roles in the pituitary gland, such as the modulation of the pituitary hormone secretion.
（前）肾素受体（(P)RR）是肾素和血管紧张素原的特异性受体，其在大鼠垂体中的表达情况已被研究。原位杂交显示，表达（P)RR mRNA 的细胞广泛分布于垂体前叶和中间叶。用原位杂交检测（P)RR mRNA 与免疫组织化学检测垂体激素的双重染色显示，（P)RR mRNA 在前叶的大多数 GH 细胞和 ACTH 细胞中表达。（P)RR mRNA 也在少数催乳素细胞和 TSH 细胞中表达，但在 LH 细胞中不表达。本研究首次显示了（P)RR mRNA 表达细胞在大鼠垂体中的分布。这些发现表明，（P)RR 在垂体中发挥生理作用，例如调节垂体激素分泌。
