细胞色素P450 17α-羟化酶/17,20-裂解酶（CYP17）T27C多态性与前列腺癌风险：基于31项研究的荟萃分析
CYP17 T27C polymorphism and prostate cancer risk: a meta-analysis based on 31 studies.
作者信息
Wei Bingbing, Zhang Yunyun, Xi Bo, Chang Junkai, Bai Jinming, Su Jiantang
机构信息
Department of Urology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China.
出版信息
J Biomed Res. 2010 May;24(3):233-41. doi: 10.1016/S1674-8301(10)60033-4.
OBJECTIVE
The cytochrome P450 17α-hydroxylase (CYP17) plays a vital role in androgen biosynthesis. A T-to-C polymorphism in the 5' promoter region of CYP17 has been implicated as a risk factor for prostate cancer, but the results of individual studies are inconclusive or controversial. To derive a more precise estimation of the relationship, we performed an updated meta-analysis from 31 studies based on 27 publications.
METHODS
A comprehensive search was conducted to examine all the eligible studies of CYP17 polymorphism and prostate cancer risk. We used odds ratios (ORs) with 95% confidence intervals (CIs) to assess the strength of the association.
RESULTS
Overall, individuals with CC/CT genotype were not associated with prostate cancer risk (CC vs. TT: OR = 1.03, 95% CI = 0.86-1.24, P = 0.72, P heterogeneity < 0.0001; CT vs. TT: OR = 0.99, 95% CI = 0.87-1.12, P = 0.88, P heterogeneity = 0.0006). In the stratified analysis by ethnicity, there was a significantly increased risk of prostate cancer among individuals of African descent under the recessive model (OR = 1.56, 95% CI = 1.01-2.39, P = 0.04, P heterogeneity = 0.65).
CONCLUSION
This meta-analysis suggested that CYP17 polymorphism might be associated with prostate cancer risk among individuals of African descent.
目的
细胞色素P450 17α-羟化酶（CYP17）在雄激素生物合成中起关键作用。CYP17基因5'启动子区域的T到C多态性被认为是前列腺癌的一个危险因素，但个别研究结果尚无定论或存在争议。为了更精确地评估两者关系，我们基于27篇出版物中的31项研究进行了一项更新的荟萃分析。
方法
进行全面检索以审查所有关于CYP17多态性与前列腺癌风险的合格研究。我们使用比值比（OR）及其95%置信区间（CI）来评估关联强度。
结果
总体而言，CC/CT基因型个体与前列腺癌风险无关（CC与TT比较：OR = 1.03，95% CI = 0.86 - 1.24，P = 0.72，P异质性<0.0001；CT与TT比较：OR = 0.99，95% CI = 0.87 - 1.12，P = 0.88，P异质性 = 0.0006）。在按种族分层分析中，在隐性模型下非洲裔个体患前列腺癌的风险显著增加（OR = 1.56，95% CI = 1.01 - 2.39，P = 0.04，P异质性 = 0.65）。
结论
这项荟萃分析表明，CYP17多态性可能与非洲裔个体的前列腺癌风险相关。
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