College of Public Health, Zhengzhou University, Zhengzhou, China.
School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, China.
Am J Mens Health. 2020 Sep-Oct;14(5):1557988320959984. doi: 10.1177/1557988320959984.
Gene polymorphism is one of the few factors that increases the risk of prostate cancer. T to C substitution in the 5' promoter region of the CYP17 gene is hypothesized to increase the rate of gene transcription, increase androgen production, and thereby increase the risk of prostate cancer. Nevertheless, the inconsistencies originating from studies on CYP17 polymorphism and prostate cancer prompted this meta-analysis, to decipher the association between CYP17 polymorphism and prostate cancer. Most case-control studies addressing CYP17 polymorphism and prostate cancer were exhaustively searched from Web of Science, Google Scholar, and PubMed. The various genotype distributions as well as the minor allele distributions were retrieved. Pooled odds ratios (s) with their 95% CI and estimates of the Hardy-Weinberg Equilibrium were calculated. Analyses were performed using the RevMan v.5.3 software and SPSS v.21. There was high-pooled heterogeneity ( = 87.0%, = .42, CI [.39, .45], and < .001) among the A2 versus A1 allele. With the per-allele model (A2 versus A1), ethnicity was a major risk factor to prostate cancer, with Asians recording the highest risk ( = 12.61, 95% CI [8.77, 18.12]). From the genotype models, A1/A1 versus A2/A2 ( = 3.02, 95% CI [2.65, 3.44]) and A1/A2 versus A2/A2 ( = 4.39, 95% CI [3.86, 5.00]) were all significantly associated with prostate cancer. Although some genotype models were associated with the risk of prostate cancer, we should be mindful when interpreting the results of this study because of the limited number of studies and the small sample size used.
基因多态性是增加前列腺癌风险的少数因素之一。CYP17 基因 5'启动子区域的 T 到 C 替换被假设可以增加基因转录率，增加雄激素的产生，从而增加前列腺癌的风险。然而，由于 CYP17 多态性与前列腺癌的研究结果不一致，促使进行了这项荟萃分析，以阐明 CYP17 多态性与前列腺癌之间的关联。从 Web of Science、Google Scholar 和 PubMed 中全面搜索了关于 CYP17 多态性和前列腺癌的病例对照研究。检索了各种基因型分布和次要等位基因分布。计算了合并优势比（OR）及其 95%置信区间（CI）和 Hardy-Weinberg 平衡估计值。使用 RevMan v.5.3 软件和 SPSS v.21 进行分析。A2 与 A1 等位基因之间存在高度合并的异质性（ = 87.0%， =.42，CI [.39，.45]， <.001）。在等位基因模型中（A2 与 A1），种族是前列腺癌的一个主要危险因素，亚洲人记录的风险最高（ = 12.61，95%CI [8.77，18.12]）。从基因型模型来看，A1/A1 与 A2/A2（ = 3.02，95%CI [2.65，3.44]）和 A1/A2 与 A2/A2（ = 4.39，95%CI [3.86，5.00]）均与前列腺癌显著相关。尽管某些基因型模型与前列腺癌的风险相关，但由于研究数量有限且使用的样本量较小，在解释研究结果时应保持谨慎。
