Zou Peng, Zhao Lin, Xu Haitao, Chen Ping, Gu Aihua, Liu Ning, Zhao Peng, Lu Ailin
Department of Neurosurgery, the First Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu 210029, China;
J Biomed Res. 2012 Jul;26(4):253-9. doi: 10.7555/JBR.26.20110122. Epub 2012 Apr 16.
MicroRNAs (miRNAs) are gene regulators involved in numerous diseases including cancer, heart disease, neurological disorders, vascular abnormalities and autoimmune conditions. Although hsa-mir-499 rs3746444 polymorphism was shown to contribute to the susceptibility of multiple genes to cancer, the data have yielded conflicting results. Therefore, this meta-analysis was performed to provide a comprehensive assessment of potential association between hsa-mir-499 rs3746444 polymorphism and cancer risk. In this meta-analysis, a total of 9 articles regarding 10 eligible case-control studies in English (including 6134 cases and 7141 controls) were analyzed. No significant association between hsa-mir-499 rs3746444 polymorphism and overall cancer risk was demonstrated. However, an increased risk was observed in the subgroup of breast cancer patients (G allele vs A allele: OR = 1.10, 95% CI = 1.00-1.20; P heterogeneity = 0.114; I (2) = 53.9%) and population-based studies (G allele vs A allele: OR = 1.12, 95% CI = 1.00-1.25; P heterogeneity = 0.062; I (2) = 64.0%). The findings suggested an association between hsa-mir-499 rs3746444 polymorphism and increased risk to breast cancer.
微小RNA（miRNA）是参与多种疾病的基因调节因子，这些疾病包括癌症、心脏病、神经紊乱、血管异常和自身免疫性疾病。尽管已表明人微小RNA-499（hsa-mir-499）rs3746444多态性与多种基因对癌症的易感性有关，但数据结果相互矛盾。因此，进行了这项荟萃分析，以全面评估hsa-mir-499 rs3746444多态性与癌症风险之间的潜在关联。在这项荟萃分析中，共分析了9篇英文文章，涉及10项符合条件的病例对照研究（包括6134例病例和7141例对照）。未证明hsa-mir-499 rs3746444多态性与总体癌症风险之间存在显著关联。然而，在乳腺癌患者亚组（G等位基因与A等位基因：比值比=1.10，95%置信区间=1.00-1.20；异质性P=0.114；I²=53.9%）和基于人群的研究（G等位基因与A等位基因：比值比=1.12，95%置信区间=1.00-1.25；异质性P=0.062；I²=64.0%）中观察到风险增加。这些发现表明hsa-mir-499 rs3746444多态性与乳腺癌风险增加之间存在关联。
