Wang Zhongxia, Wu Junhua, Zhang Guang, Cao Yin, Jiang Chunping, Ding Yitao
Department of Hepatobiliary Surgery, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu 210008, China ; Jiangsu Province's Key Medical Center for Liver Surgery, Nanjing, Jiangsu 210008, China.
Gastroenterol Res Pract. 2013;2013:719202. doi: 10.1155/2013/719202. Epub 2013 Sep 26.
Background. Hepatocellular carcinoma (HCC) represents the sixth common cancer in the world. Single nucleotide polymorphisms (SNPs) in microRNA genes may be associated with susceptibility to HCC. Recently, several studies have reported possible associations of SNPs miR-499 T>C rs3746444 and miR-34b/c T>C rs4938723 with the risk of HCC. However the results are inconsistent and inconclusive. In this present study, we conducted a meta-analysis to comprehensively evaluate potential associations between the two SNPs and HCC susceptibility. Methods. Through a systematic literature search, 8-case-control studies involving 5464 subjects were identified and included in this meta-analysis. The association between the two common SNPs and HCC risk was estimated by pooled odds ratios (ORs) and 95% confidence intervals (95% CIs). Our results showed no significant association between rs3746444 and susceptibility to HCC, whereas variant genotypes of rs4938723 were associated with increased HCC risk in allele frequency model and heterozygous model (C versus T, OR = 1.11, 95% CI: 1.01-1.23, P = 0.04; TC versus TT, OR = 1.19, 95% CI: 1.03-1.37, P = 0.02). Conclusions. The current evidence did not support association between rs3746444 and HCC risk. SNP rs4938723 may be associated with susceptibility to HCC. Further well-designed studies are required to clarify the relationships between the two SNPs and HCC risk.
背景。肝细胞癌（HCC）是全球第六大常见癌症。微小RNA基因中的单核苷酸多态性（SNP）可能与HCC易感性相关。最近，几项研究报告了SNP miR - 499 T>C rs3746444和miR - 34b/c T>C rs4938723与HCC风险之间可能存在的关联。然而，结果并不一致且尚无定论。在本研究中，我们进行了一项荟萃分析，以全面评估这两个SNP与HCC易感性之间的潜在关联。方法。通过系统的文献检索，确定了8项涉及5464名受试者的病例对照研究，并纳入本荟萃分析。通过合并比值比（OR）和95%置信区间（95%CI）估计这两个常见SNP与HCC风险之间的关联。我们的结果显示，rs3746444与HCC易感性之间无显著关联，而rs4938723的变异基因型在等位基因频率模型和杂合子模型中与HCC风险增加相关（C对T，OR = 1.11，95%CI：1.01 - 1.23，P = 0.04；TC对TT，OR = 1.19，95%CI：1.03 - 1.37，P = 0.02）。结论。目前的证据不支持rs3746444与HCC风险之间的关联。SNP rs4938723可能与HCC易感性相关。需要进一步设计良好的研究来阐明这两个SNP与HCC风险之间的关系。
