Tateno Kaoru, Minamino Tohru, Moriya Junji, Katada Akemi, Yokoyama Masataka, Miura Kentaro, Komuro Issei
Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, Chiba, Japan.
Ann Vasc Dis. 2008;1(2):66-79. doi: 10.3400/avd.AVDsr00108. Epub 2008 Oct 24.
There have been great progresses in our knowledge of patho-physiology on various cardiovascular diseases, which enabled us to develop the field of regenerative medicine for previously untreatable patients. Among several strategies in cardiovascular regenerative medicine, cell transplantation is one of the best studied and the best clinically practiced. In this review we will first summarize the mechanisms of cell therapy, and then go through lists of cells and diseases that can be applied. Later we will introduce some of the clinical experiences published so far, with some discussion regarding the problems and perspectives of this novel therapeutics.
我们对各种心血管疾病病理生理学的认识取得了巨大进展，这使我们能够为以前无法治疗的患者开拓再生医学领域。在心血管再生医学的几种策略中，细胞移植是研究最深入且临床应用最广泛的方法之一。在这篇综述中，我们将首先总结细胞治疗的机制，然后梳理可应用的细胞和疾病清单。随后，我们将介绍目前已发表的一些临床经验，并对这种新型治疗方法的问题和前景进行一些讨论。
