Jung Jin M, Fridman Alexander, Cho Daniel J, Cho Young I
Department of Mechanical Engineering and Mechanics, Drexel University, Philadelphia, Pennsylvania 19104, USA.
Rev Sci Instrum. 2013 Mar;84(3):034301. doi: 10.1063/1.4797478.
The present study investigated the feasibility of applying pulsed corona discharges to blood plasma to reduce the viscosity of blood plasma and whole blood. Blood plasma was separated from blood cells, treated with corona discharges, and filtered before it was re-mixed with blood cells. Plasma viscosity (PV), whole blood viscosity (WBV), and low-density lipoprotein (LDL)-c concentration were measured before and after the corona treatment and filtration. Both PV and WBV increased in the case of the corona treatment only, whereas both of them decreased in the case of the corona treatment plus filtration. In particular, the LDL-c decreased in the case of the corona treatment plus filtration by 31.5% from the baseline value. The effect of the corona treatment on the reduction of the WBV was significant at low shear rates, but not at high shear rates, suggesting that the precipitation of the molecules in blood plasma by the corona treatment and subsequent removal may suppress the aggregation of erythrocytes and improve rheological properties of blood.
本研究探讨了应用脉冲电晕放电处理血浆以降低血浆和全血粘度的可行性。将血浆与血细胞分离，用电晕放电处理，过滤后再与血细胞重新混合。在电晕处理和过滤前后测量血浆粘度（PV）、全血粘度（WBV）和低密度脂蛋白（LDL）-c浓度。仅进行电晕处理时，PV和WBV均升高，而电晕处理加过滤时，二者均降低。特别是，电晕处理加过滤时，LDL-c较基线值降低了31.5%。电晕处理对降低WBV的作用在低剪切速率下显著，但在高剪切速率下不显著，这表明电晕处理使血浆中的分子沉淀并随后去除可能抑制红细胞聚集并改善血液的流变学特性。
