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采用补充酮酸的极低蛋白饮食(VLPD+KA)降低与紧急透析相关的发病率。

Reduction of morbidity related to emergency access to dialysis with very low protein diet supplemented with ketoacids (VLPD+KA).

作者信息

Duenhas Marta, Gonçalves Elsa, Dias Mônica, Leme Graziela, Laranja Sandra

机构信息

Nephrology Division, Hospital do Servidor Público Estadual, São Paulo, Brazil.

出版信息

Clin Nephrol. 2013 May;79(5):387-93. doi: 10.5414/CN107460.

Abstract

OBJECTIVE

To delay the beginning of the renal replacement therapy (RRT) until the AV fistula is either made and mature or the training for peritoneal dialysis (PD) is given.

DESIGN

Prospective study.

SETTING

Nephrology's Ambulatory, Hospital Servidor Público Estadual.

PATIENTS

21 patients with chronic kidney disease (CKD) have been followed.

METHODS

For a period of 30 days, a VLPD+KA would be prescribed until the AV fistula was made or the PD training was given The patients were evaluated prior to the beginning of the VLPD+KA, on the 15th and the 30th day, and at the end of the study, with physical and nutritional evaluation, laboratory tests and 24-hour excretion of urinary urea and urinary protein, creatinine and urea residual clearance.

RESULTS

47.6% (10/21) of the patients have initiated HD with matured and suitable AV fistula made in 30 days; 33.3% (7/21) of the patients have been unfit to initiate RRT, even though with sufficient time for the creation of the AV fistula or the training for PD due to AV fistula thrombosis; 14.3% (3/21) of the patients have remained in the study with no need for dialysis, and 4.8% (1/21) have been excluded on the grounds of not having adhered to the VLPD+KA. The anthropometric parameters and the energy intake have not differed from one period to the other.

CONCLUSION

The VLPD+KA is safe to maintain the nutritional status of patients of CKD until the AV fistula is made or the PD training is given.

摘要

目的

将肾脏替代治疗(RRT)的开始时间推迟到动静脉内瘘建立并成熟或完成腹膜透析(PD)培训之时。

设计

前瞻性研究。

地点

州立公立医院肾脏病门诊。

患者

对21例慢性肾脏病(CKD)患者进行了随访。

方法

在30天的时间里,开具极低蛋白饮食+酮酸(VLPD+KA)处方,直到建立动静脉内瘘或进行PD培训。在VLPD+KA开始前、第15天、第30天以及研究结束时,对患者进行评估,包括身体和营养评估、实验室检查以及24小时尿尿素、尿蛋白、肌酐排泄量和尿素清除率。

结果

47.6%(10/21)的患者在30天内通过建立成熟且合适的动静脉内瘘开始了血液透析;33.3%(7/21)的患者因动静脉内瘘血栓形成,即使有足够时间建立动静脉内瘘或进行PD培训,仍不适合开始RRT;14.3%(3/21)的患者无需透析,仍留在研究中,4.8%(1/21)的患者因未坚持VLPD+KA被排除。人体测量参数和能量摄入在各阶段之间没有差异。

结论

在建立动静脉内瘘或进行PD培训之前,VLPD+KA对于维持CKD患者的营养状况是安全的。

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