Department of Pathology, Microbiology, and Immunology, University of South Carolina, School of Medicine, Columbia, SC 29209, USA.
Cytokine. 2013 May;62(2):202-5. doi: 10.1016/j.cyto.2013.03.010. Epub 2013 Apr 1.
Interleukin (IL)-27 is a unique cytokine that has a dual role in immune responses. It was originally described to promote Th1 differentiation but also suppresses inflammation by inhibiting these and other inflammatory T cell subsets. Inhibition of inflammatory activity in macrophages has also been reported. These reports have largely focused on cytokine profiles or signaling mechanisms. To date, there have been no reports of how IL-27 may directly influence cellular mechanisms that operate to control microbial growth. Formation of a phagolysosome that acquires antimicrobial properties is an essential step for destruction of pathogens or pathogen-derived materials that are internalized by macrophages. Here we report that IL-27 has a profound influence on this critical innate immunity pathway. Treatment of human macrophages with IL-27 interferes with the acidification of phagosomes by reducing protein levels of V-ATPase and impairs control of bacterial pathogens.
白细胞介素 (IL)-27 是一种独特的细胞因子，在免疫反应中具有双重作用。它最初被描述为促进 Th1 分化，但也通过抑制这些和其他炎症性 T 细胞亚群来抑制炎症。也有报道称其抑制巨噬细胞的炎症活性。这些报告主要集中在细胞因子谱或信号转导机制上。迄今为止，还没有报道表明 IL-27 如何直接影响控制微生物生长的细胞机制。形成具有抗菌特性的吞噬体是巨噬细胞吞噬和破坏病原体或病原体衍生物质的关键步骤。在这里，我们报告 IL-27 对这条关键的先天免疫途径有深远的影响。用 IL-27 处理人巨噬细胞会通过降低 V-ATPase 的蛋白水平干扰吞噬体的酸化，并损害对细菌病原体的控制。
