The Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences/Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Cytokine. 2013 May;62(2):175-82. doi: 10.1016/j.cyto.2013.03.014. Epub 2013 Apr 1.
Interleukin-17 (IL-17), the signature cytokine produced by T helper 17 (Th17) cells, plays pivotal roles in host defense responses against microbial invasion, as well as in the pathogenesis of autoimmune diseases and allergic syndromes. IL-17 activates several downstream signaling pathways including NF-κB, MAPKs and C/EBPs to induce gene expression of antibacterial peptides, proinflammatory chemokines and cytokines and matrix metalloproteinases (MMPs). IL-17 can also stabilize mRNAs of genes induced by TNFα. Although the physiological and pathological functions of IL-17 have been studied for many years, the landscape of its signaling transduction has not been described until recently. The cytosolic adaptor molecule Act1 (also known as CIKS) is considered as the master mediator of IL-17 signaling. In this review, we will summarize recent progress on activation and regulation of IL-17 mediated signal transduction, especially on Act1 mediated regulation of the signaling.
白细胞介素-17（IL-17）是辅助性 T 细胞 17（Th17）细胞产生的标志性细胞因子，在宿主抵御微生物入侵的防御反应以及自身免疫性疾病和过敏综合征的发病机制中发挥关键作用。IL-17 激活包括 NF-κB、MAPKs 和 C/EBPs 在内的几种下游信号通路，诱导抗菌肽、促炎趋化因子和细胞因子以及基质金属蛋白酶（MMPs）的基因表达。IL-17 还可以稳定 TNFα 诱导的基因的 mRNA。尽管已经对 IL-17 的生理和病理功能进行了多年研究，但直到最近才描述了其信号转导的全貌。细胞质衔接分子 Act1（也称为 CIKS）被认为是 IL-17 信号转导的主要介质。在这篇综述中，我们将总结最近关于 IL-17 介导的信号转导激活和调节的进展，特别是关于 Act1 介导的信号调节。
