Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan(2); Department of Psychiatry, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan.
Neuroimage. 2014 Jan 15;85 Pt 1:508-17. doi: 10.1016/j.neuroimage.2013.03.052. Epub 2013 Apr 2.
Near-infrared spectroscopy (NIRS) studies have reported that prefrontal hemodynamic dysfunction during executive function tasks may be a promising biomarker of psychiatric disorders, because its portability and noninvasiveness allow easy measurements in clinical settings. Here, we investigated the degree to which prefrontal NIRS signals are genetically determined. Using a 52-channel NIRS system, we monitored the oxy-hemoglobin (oxy-Hb) signal changes in 38 adult pairs of right-handed monozygotic (MZ) twins and 13 pairs of same-sex right-handed dizygotic (DZ) twins during a letter version of the verbal fluency task. Heritability was estimated based on a classical twin paradigm using structured equation modeling. Significant genetic influences were estimated in the right dorsolateral prefrontal cortex and left frontal pole. The degrees of heritability were 66% and 75% in the variances, respectively. This implies that the prefrontal hemodynamic dysfunction observed during an executive function task measured by NIRS may be an efficient endophenotype for large-scale imaging genetic studies in psychiatric disorders.
近红外光谱（NIRS）研究报告称，执行功能任务期间前额叶血液动力学功能障碍可能是精神疾病的有前途的生物标志物，因为其便携性和非侵入性允许在临床环境中进行轻松测量。在这里，我们研究了前额叶 NIRS 信号在多大程度上是由遗传决定的。使用 52 通道 NIRS 系统，我们在言语流畅性任务的字母版本中监测了 38 对右利手同卵（MZ）双胞胎和 13 对同性别右利手异卵（DZ）双胞胎的 38 对右利手同卵（MZ）双胞胎和 13 对同性别右利手异卵（DZ）双胞胎的氧合血红蛋白（oxy-Hb）信号变化。使用结构方程模型基于经典的双胞胎范例估计遗传力。在右背外侧前额叶皮层和左额极中估计出显著的遗传影响。方差的遗传度分别为 66％和 75％。这意味着通过 NIRS 测量的执行功能任务期间观察到的前额叶血液动力学功能障碍可能是精神疾病大规模成像遗传研究的有效内表型。
