Department of Psychology, The University of Texas at Austin, Austin, Texas, United States of America.
Institute for Mental Health Research, The University of Texas at Austin, Austin, Texas, United States of America.
PLoS One. 2018 Jun 13;13(6):e0198950. doi: 10.1371/journal.pone.0198950. eCollection 2018.
The current research examined whether carriers of the short 5-HTTLPR allele (in SLC6A4), who have been shown to selectively attend to negative information, exhibit a bias towards negative self-referent processing. The self-referent encoding task (SRET) was used to measure self-referential processing of positive and negative adjectives. Ratcliff's diffusion model isolated and extracted decision-making components from SRET responses and reaction times. Across the initial (N = 183) and replication (N = 137) studies, results indicated that short 5-HTTLPR allele carriers more easily categorized negative adjectives as self-referential (i.e., higher drift rate). Further, drift rate was associated with recall of negative self-referential stimuli. Findings across both studies provide further evidence that genetic variation may contribute to the etiology of negatively biased processing of self-referent information. Large scale studies examining the genetic contributions to negative self-referent processing may be warranted.
当前的研究考察了携带 SLC6A4 短 5-HTTLPR 等位基因（被证明选择性地关注负面信息）的个体是否表现出对负面自我参照信息处理的偏向。自我参照编码任务（SRET）用于测量积极和消极形容词的自我参照加工。Ratcliff 的扩散模型从 SRET 反应和反应时间中分离并提取决策成分。在初步研究（N=183）和复制研究（N=137）中，结果表明短 5-HTTLPR 等位基因携带者更容易将消极形容词归类为自我参照（即，更高的漂移率）。此外，漂移率与消极自我参照刺激的回忆相关。两项研究的结果都进一步证明，遗传变异可能导致对自我参照信息的负面偏向处理。可能需要进行大规模研究来检验遗传因素对负面自我参照信息处理的影响。
