Diagnostic Breast Clinic, Casa di Cura Dott. Pederzoli, Peschiera del Garda, Italy.
Breast. 2013 Oct;22(5):806-9. doi: 10.1016/j.breast.2013.02.010. Epub 2013 Apr 1.
To evaluate increment cancer detection rate generated by ultrasound (US).
US only detected cancers were assessed for 22,131 self-referring asymptomatic women with negative mammography and subgroups by age, previous cancer, breast density. Invasive assessment and surgical biopsy rate were evaluated.
The overall US detection was 1.85 per thousand (41/22,131). In the subgroups it was: 1.95 per thousand (22/11,274) in women <50 years vs 1.75 per thousand (19/10,857) in women ≥ 50 years (p = 0.42), 5.49 per thousand (12/2183) in women with previous cancer vs 1.45 per thousand (29/19,948) in women without cancer history (p = 0.0004), 2.21 per thousand (22/9960) in dense breasts (p = 0.17) vs 1.56 per thousand (19/12,171) in fatty breasts. The US generated invasive assessment was 1.9% (422/22,131). The benign to malignant open surgical biopsy ratio was 0.17 (7/41).
Adding US to negative mammography allowed for substantial incremental cancer detection rate (1.85 per thousand), particularly at age <50 years, in women with previous breast cancer and in dense breasts.
评估超声（US）检查增加的癌症检出率。
评估了 22131 名自我转诊的无症状、乳腺 X 线摄影检查阴性且按年龄、既往癌症、乳腺密度分组的女性中仅由 US 检出的癌症。评估了侵袭性评估和外科活检率。
总体 US 检出率为千分之 1.85（41/22131）。在亚组中，<50 岁的女性为千分之 1.95（22/11274），≥50 岁的女性为千分之 1.75（19/10857）（p=0.42），有既往癌症史的女性为千分之 5.49（12/2183），无癌症史的女性为千分之 1.45（29/19948）（p=0.0004），致密乳腺的 US 检出率为千分之 2.21（22/9960），脂肪乳腺的 US 检出率为千分之 1.56（19/12171）（p=0.17）。US 检查导致的侵袭性评估为 1.9%（422/22131）。良性至恶性开放外科活检的比值为 0.17（7/41）。
将 US 检查加入到阴性乳腺 X 线摄影检查中，可显著提高癌症检出率（千分之 1.85），尤其是在<50 岁、有既往乳腺癌病史和致密乳腺的女性中。
