Cory D G, Garroway A N
Chemistry Division, Naval Research Laboratory, Washington, D.C. 20375-5000.
Magn Reson Med. 1990 Jun;14(3):435-44. doi: 10.1002/mrm.1910140303.
We introduce and demonstrate an NMR pulsed gradient stimulated echo method of directly obtaining the molecular translational displacement probability (displacement profile) of a liquid. The temporal development of the displacement profile reflects the presence of diffusion, restrictions to diffusion (e.g., walls, membranes), flow, and spatially dependent relaxation sinks. This approach allows the study of compartments which are too small to be observed by conventional NMR imaging methods. The distribution of spatial properties of compartments can be characterized over a spatial field of about 0.1 to 25 microns, completely independent of the absolute spatial location of the individual compartments.
我们介绍并演示了一种核磁共振脉冲梯度刺激回波方法，该方法可直接获取液体的分子平移位移概率（位移分布）。位移分布随时间的变化反映了扩散、扩散受限（如壁、膜）、流动以及空间相关弛豫阱的存在。这种方法允许研究那些太小而无法用传统核磁共振成像方法观察到的隔室。隔室空间特性的分布可以在约0.1至25微米的空间场中进行表征，完全独立于各个隔室的绝对空间位置。
