Skau K A
Division of Pharmacology and Medicinal Chemistry, College of Pharmacy, University of Cincinnati, OH 45267.
Muscle Nerve. 1990 Apr;13(4):321-5. doi: 10.1002/mus.880130407.
The tetrameric form of acetylcholinesterase (AChE) in ReJ/129 dystrophic mice was demonstrated to be absent from endplate-poor regions of skeletal muscle but present in endplate-rich regions. Skeletal muscle secreted normal amounts of this form of AChE. Visceral organs had normal amounts and distribution of the AChE molecular forms. These results suggest that the AChE defect in dystrophic mice is limited to skeletal muscle, and the defect does not reflect an abnormality of AChE synthesis but probably reflects an inability to incorporate the enzyme into skeletal muscle membranes.
在ReJ/129营养不良小鼠中，已证实骨骼肌终板较少区域不存在乙酰胆碱酯酶（AChE）的四聚体形式，而在终板丰富区域则存在。骨骼肌分泌正常量的这种形式的AChE。内脏器官中AChE分子形式的量和分布正常。这些结果表明，营养不良小鼠中的AChE缺陷仅限于骨骼肌，并且该缺陷并不反映AChE合成异常，而可能反映了无法将该酶整合到骨骼肌膜中。
