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在加拿大不列颠哥伦比亚省,药物治疗方案不充分的哮喘患者对卫生服务的高利用率:一项基于人群的评估。

High use of health services in patients with suboptimal asthma drug regimens: a population-based assessment in British Columbia, Canada.

机构信息

Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, British Columbia, Canada.

出版信息

Pharmacoepidemiol Drug Saf. 2013 Jul;22(7):744-51. doi: 10.1002/pds.3444. Epub 2013 Apr 5.

Abstract

BACKGROUND

Despite numerous clinical guidelines on asthma management, patients often receive suboptimal drug therapy. This study identified patients who received suboptimal regimens according to the National Heart, Lung and Blood Institute (NHLBI) Guidelines for the Diagnosis and Management of Asthma in a complete population (residents of British Columbia, Canada) and determined the association between patients' regimens and utilization of healthcare services.

METHODS

A total of 65,345 asthma patients were identified using provincial health service utilization data (including all respiratory-related prescription medication dispensings, physician and hospital visits) for the 2009 fiscal year. Patient-specific regimens of inhaled short-acting bronchodilators (SABA) with or without inhaled corticosteroids (ICS) were categorized as optimal or suboptimal. Logistic regression models were used to determine the association between regimen optimality and health service utilization, adjusted for socioeconomic status, prior year hospital and emergency department (ED) visits for asthma.

RESULTS

Patients with suboptimal regimens had significantly greater risk of using health services than patients with optimal regimens of SABA and/or ICS. In particular, adolescents with suboptimal regimens were the most likely to have hospital admissions (odds ratio (OR) 3.8; 95% confidence interval (CI) 1.8-7.8), visit the ED (OR 2.2; 95% CI 1.6-3.1) and be high users of family physician services (OR 5.7; 95% CI 4.0-8.1) compared with patients in other age groups.

CONCLUSIONS

Suboptimal regimens are associated with significantly high usage of health services. Identifying patients with suboptimal regimens and improving their medication management in accordance with asthma clinical guidelines are likely to result in lower health service utilization.

摘要

背景

尽管有许多关于哮喘管理的临床指南,但患者通常接受的药物治疗并不理想。本研究根据美国国立心肺血液研究所(NHLBI)的哮喘诊断和管理指南,在一个完整的人群(加拿大不列颠哥伦比亚省的居民)中确定了接受不适当治疗方案的患者,并确定了患者治疗方案与医疗服务利用之间的关联。

方法

使用 2009 财年省级卫生服务利用数据(包括所有与呼吸相关的处方药物配给、医生和医院就诊),共确定了 65345 例哮喘患者。吸入性短效支气管扩张剂(SABA)联合或不联合吸入性皮质类固醇(ICS)的患者特定治疗方案分为最佳或不理想。使用逻辑回归模型,调整社会经济地位、前一年因哮喘住院和急诊就诊情况,确定治疗方案的优劣与卫生服务利用之间的关联。

结果

与接受最佳 SABA 和/或 ICS 治疗方案的患者相比,接受不理想治疗方案的患者使用卫生服务的风险显著更高。特别是,接受不理想治疗方案的青少年最有可能住院(比值比(OR)3.8;95%置信区间(CI)1.8-7.8)、去急诊(OR 2.2;95% CI 1.6-3.1)和高频率使用家庭医生服务(OR 5.7;95% CI 4.0-8.1),与其他年龄组的患者相比。

结论

不理想的治疗方案与卫生服务的高利用率显著相关。确定接受不理想治疗方案的患者并根据哮喘临床指南改善其药物管理,可能会降低卫生服务的利用。

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