Koca Gokhan, Atilgan Hasan Ikbal, Demirel Koray, Diri Akif, Korkmaz Meliha
Department of Nuclear Medicine, Ministry of Health, Ankara Training and Research Hospital, Ulucanlar, Altindag, Ankara, Turkey.
Indian J Nucl Med. 2011 Oct;26(4):185-7. doi: 10.4103/0972-3919.106701.
Tc-99m dimercaptosuccinic acid (DMSA) is filtered through the glomeruli and reabsorbed by the proximal tubules as low molecular weight proteins. In Lowe syndrome this mechanism is impaired and so poor DMSA uptake is seen. Poor DMSA uptake was shown in very few studies, but none mentioned normal Tc-99m MAG3 uptake. In this case, the patient had poor DMSA uptake, normal MAG3 uptake and a neurogenic bladder in anterior to the left kidney that attenuates left kidney.
锝-99m二巯基丁二酸（DMSA）经肾小球滤过，并作为低分子量蛋白质被近端小管重吸收。在 Lowe 综合征中，这一机制受损，因此可见 DMSA 摄取不良。很少有研究显示 DMSA 摄取不良，但均未提及锝-99m 巯基乙酰三甘氨酸（MAG3）摄取正常。在本病例中，患者 DMSA 摄取不良，MAG3 摄取正常，且左肾前方有一神经源性膀胱，使左肾显影减弱。
