Damle Nishikant, Ramya Soundararajan, Bal Chandrasekhar, Durgapal Prashant
Department of Nuclear Medicine, AIIMS, New Delhi, India.
Indian J Nucl Med. 2011 Oct;26(4):196-8. doi: 10.4103/0972-3919.106707.
Solid variant is a rare and poorly characterized variant of papillary thyroid carcinoma (PTC) and comprises approximately 3% of PTCs. It is more common in children and has high propensity for extrathyroidal metastasis. It is seen in higher proportion in post-radiation PTCs and has been seen in more than one-third of post Chernobyl radiation induced PTCs in some studies. It usually presents with differential diagnosis of poorly differentiated carcinoma versus anaplastic versus medullary thyroid carcinoma versus metastasis from extrathyroidal malignancy on fine needle aspiration cytology. This report describes a case of solid variant of PTC in a child who had no history of radiation exposure and shows the importance to be given to histopathology when the pre-operative diagnosis is not clear.
实性变体是甲状腺乳头状癌（PTC）的一种罕见且特征描述较少的变体，约占PTC的3%。它在儿童中更常见，且具有较高的甲状腺外转移倾向。在放疗后的PTC中比例更高，在一些研究中，超过三分之一的切尔诺贝利辐射诱发的PTC中可见到。在细针穿刺细胞学检查中，它通常表现为与低分化癌、间变性癌、甲状腺髓样癌以及甲状腺外恶性肿瘤转移的鉴别诊断。本报告描述了一例无辐射暴露史的儿童PTC实性变体病例，并显示了术前诊断不明确时组织病理学的重要性。
