Al-Mohaimeed Mansour M
Head of Ophthalmology Department, College of Medicine, Qassim University, Qassim, Kingdom of Saudi Arabia.
Int J Health Sci (Qassim). 2013 Jan;7(1):67-74. doi: 10.12816/0006023.
To evaluate the complications, and visual and graft survival outcomes in eyes that had undergone penetrating keratoplasty (PKP) for keratoconus.
This restrospective study includes 311 patients with keratoconus who had undergone PKP between January 1, 2001, and December 31, 2002, at King Khaled Eye Specialist Hospital. All patients were followed up postoperatively (maximum follow-up, 65.77 months).
The mean age of patients with keratoconus at transplantation was 23.72 years. A preoperative best spectacle-corrected visual acuity (BSCVA) OF 20/40 or better was achieved in 13 eyes (4.2%). At a mean follow-up of 27 months, 212 eyes (68.2%) achieved a BSCVA of 20/40 or better. Postoperative visual acuity was significantly associated with preoperative visual acuity (P < 0.00). Only 6 eyes (1.9%) experienced graft failure, with a mean follow-up of 23.62 months. The graft rejection rate (6.8%) was a significant risk factor for failure (P = 0.00). Age, gender, corneal graft diameter, and intraoperative vitreous loss had no statistically significant effects on the PKP outcome (P> 0.05). Kaplan-Meier analysis revealed that the probabilities of graft survival were 99.8% at 1 year and 97.6% at 5 years after transplantation.
Performing PKP in eyes with keratoconus is associated with good visual results and an excellent graft outcome.
评估圆锥角膜患者行穿透性角膜移植术（PKP）后的并发症、视力及植片存活情况。
本回顾性研究纳入了2001年1月1日至2002年12月31日在沙特国王哈立德眼科专科医院接受PKP的311例圆锥角膜患者。所有患者均进行了术后随访（最长随访65.77个月）。
圆锥角膜患者移植时的平均年龄为23.72岁。13只眼（4.2%）术前最佳矫正视力（BSCVA）达到20/40或更好。平均随访27个月时，212只眼（68.2%）的BSCVA达到20/40或更好。术后视力与术前视力显著相关（P<0.00）。仅6只眼（1.9%）发生植片失败，平均随访23.62个月。植片排斥率（6.8%）是失败的显著危险因素（P = 0.00）。年龄、性别、角膜植片直径和术中玻璃体脱出对PKP结果无统计学显著影响（P>0.05）。Kaplan-Meier分析显示，移植后1年植片存活概率为99.8%，5年为97.6%。
圆锥角膜患者行PKP可获得良好的视力结果和优异的植片结局。
