秀丽隐杆线虫雌雄同体的性腺形态发生和远端末梢细胞迁移。
Gonad morphogenesis and distal tip cell migration in the Caenorhabditis elegans hermaphrodite.
作者信息
Wong Ming-Ching, Schwarzbauer Jean E
机构信息
Department of Molecular Biology, Princeton University, Princeton, NJ, USA.
出版信息
Wiley Interdiscip Rev Dev Biol. 2012 Jul-Aug;1(4):519-31. doi: 10.1002/wdev.45.
Abstract
Cell migration and morphogenesis are key events in tissue development and organogenesis. In Caenorhabditis elegans, the migratory path of the distal tip cells determines the morphology of the hermaphroditic gonad. The distal tip cells undergo a series of migratory phases interspersed with turns to form the gonad. A wide variety of genes have been identified as crucial to this process, from genes that encode components and modifiers of the extracellular matrix to signaling proteins and transcriptional regulators. The connections between extracellular and transmembrane protein functions and intracellular pathways are essential for distal tip cell migration, and the integration of this information governs gonad morphogenesis and determines gonad size and shape.
摘要
细胞迁移和形态发生是组织发育和器官形成中的关键事件。在秀丽隐杆线虫中，远端尖端细胞的迁移路径决定了雌雄同体性腺的形态。远端尖端细胞经历一系列穿插着转向的迁移阶段以形成性腺。从编码细胞外基质成分和修饰因子的基因到信号蛋白和转录调节因子，各种各样的基因已被确定对这一过程至关重要。细胞外和跨膜蛋白功能与细胞内途径之间的联系对于远端尖端细胞迁移至关重要，并且这些信息的整合控制着性腺形态发生并决定性腺的大小和形状。
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