Vicente-Manzanares Miguel, Horwitz Alan Rick
Department of Cell Biology, University of Virginia School of Medicine, Charlottesville, VA, USA.
Methods Mol Biol. 2011;769:1-24. doi: 10.1007/978-1-61779-207-6_1.
Cell migration is a fundamental process that controls morphogenesis and inflammation. Its deregulation causes or is part of many diseases, including autoimmune syndromes, chronic inflammation, mental retardation, and cancer. Cell migration is an integral part of the cell biology, embryology, immunology, and neuroscience fields; as such, it has benefited from quantum leaps in molecular biology, biochemistry, and imaging techniques, and the emergence of the genomic and proteomic era. Combinations of these techniques have revealed new and exciting insights that explain how cells adhere and move, how the migration of multiple cells are coordinated and regulated, and how the cells interact with neighboring cells and/or react to changes in their microenvironment. This introduction provides a primer of the molecular and cellular insights, particularly the signaling networks, which control the migration of individual cells as well as collective migrations. The rest of the chapters are devoted to describe in detail some of the most salient technical advances that have illuminated the field of cell migration in recent years.
细胞迁移是一个控制形态发生和炎症的基本过程。其失调会导致许多疾病或成为这些疾病的一部分，包括自身免疫综合征、慢性炎症、智力迟钝和癌症。细胞迁移是细胞生物学、胚胎学、免疫学和神经科学领域不可或缺的一部分；因此，它受益于分子生物学、生物化学和成像技术的巨大飞跃，以及基因组和蛋白质组时代的出现。这些技术的结合揭示了新的、令人兴奋的见解，解释了细胞如何黏附与移动、多个细胞的迁移如何协调与调控，以及细胞如何与邻近细胞相互作用和/或对其微环境的变化做出反应。本引言提供了分子和细胞见解的入门知识，特别是信号网络，其控制单个细胞的迁移以及集体迁移。其余各章致力于详细描述近年来阐明细胞迁移领域的一些最显著的技术进展。
