Litao Miguel Lorenzo Silva, Pilar-Arceo Carlene Pc, Legaspi Gerardo Dizon
Department of Neurosciences, University of the Philippines -Manila College of Medicine, Quezon City, Philippines.
Asian J Neurosurg. 2012 Oct;7(4):174-80. doi: 10.4103/1793-5482.106649.
Arteriovenous malformation (AVM) compartments are thought as independently fed, hemodynamically independent components of the AVM nidus. Its possible role in modulating transnidal pressures have not been investigated to our knowledge.
To investigate if AVM compartments play a role in modulating transnidal pressures by using electrical models as a method of investigation.
Monocompartmental and multicompartmental AVM models were constructed using electrical circuits- building on Dr. Guglielmi's previous work. Each compartment was fed by two feeding arteries (resistors) and had a shared draining vein with other compartments in the AVM nidus. Each compartment is composed of a series of resistors which represents the pressure gradient along the AVM (arterial, arteriolar, venular, and venous). Pressure (voltage) readings were obtained within these nidal points.
The pressure gradient (venous-arterial) is more as there are less AVM compartments in the nidus model. The monocomparmental model had a pressure gradient of 66mmHg (V); while it was 64, 61, and 59 for the 2-, 3-, and 4-compartment models, respectively. In addition, the more the number of compartments, the greater the flow (mA) is in the whole AVM nidus, 33 ml/min for the monocompartmental AVM and 121ml/min for the 4-compartment AVM; though there was greater flow per compartment as there were less compartments, 33ml/min per compartment for the monocompartmental model versus 29ml/min for the 4-compartment model.
Transnidal pressure gradients may be less the more compartments an AVM has. This electrical model represents an approach that can be used in investigating the hemodynamic contributions of AVM compartments.
动静脉畸形（AVM）腔室被认为是AVM病灶中独立供血、血流动力学独立的组成部分。据我们所知，其在调节经病灶压力方面的可能作用尚未得到研究。
通过使用电模型作为研究方法，探讨AVM腔室在调节经病灶压力方面是否起作用。
基于古列尔米博士之前的工作，使用电路构建单腔室和多腔室AVM模型。每个腔室由两条供血动脉（电阻）供血，并与AVM病灶中的其他腔室共用一条引流静脉。每个腔室由一系列电阻组成，代表沿AVM（动脉、小动脉、小静脉和静脉）的压力梯度。在这些病灶点获取压力（电压）读数。
病灶模型中的AVM腔室越少，压力梯度（静脉-动脉）越大。单腔室模型的压力梯度为66mmHg（V）；而双腔室、三腔室和四腔室模型的压力梯度分别为64mmHg、61mmHg和59mmHg。此外，腔室数量越多，整个AVM病灶中的血流量（mA）就越大，单腔室AVM为33ml/min，四腔室AVM为121ml/min；尽管每个腔室的血流量随着腔室数量减少而更大，单腔室模型为每个腔室33ml/min，四腔室模型为每个腔室29ml/min。
AVM的腔室越多，经病灶压力梯度可能越小。这种电模型代表了一种可用于研究AVM腔室血流动力学贡献的方法。
