Barker P M, Markiewicz M, Parker K A, Walters D V, Strang L B
Department of Paediatrics, University College and Middlesex School of Medicine, Rayne Institute, London, United Kingdom.
Pediatr Res. 1990 Jun;27(6):588-91. doi: 10.1203/00006450-199006000-00010.
The influence of triiodothyronine and hydrocortisone on maturation of the response to epinephrine that leads to reabsorption of lung liquid was investigated in nine chronically catheterized fetal sheep. Experiments were performed on thyroidectomized fetal sheep at 116-120 d gestation, well before the reabsorptive response to epinephrine is normally seen. After i.v. administration of either triiodothyronine (60 micrograms/d) or hydrocortisone (10 mg/d) for 3 d (three fetuses in each case), all fetuses continued to secrete lung liquid during exposure to epinephrine (secretion rate = 5.9 +/- 3.2 mL/h in triiodothyronine-treated and 4.4 +/- 1.9 mL/h in hydrocortisone-treated fetuses). However, when the two hormones were administered together in the same doses to three fetuses, a striking reabsorptive response to epinephrine was seen (absorption rate = -12.3 +/- 3.6 mL/h), similar to that observed in the mature fetus. Induction of this capacity to reabsorb lung liquid may be of importance in the management of respiratory problems of the newborn infant.
在9只长期插管的胎羊中研究了三碘甲状腺原氨酸和氢化可的松对导致肺液重吸收的肾上腺素反应成熟的影响。实验在妊娠116 - 120天的甲状腺切除胎羊身上进行，这远早于正常情况下对肾上腺素的重吸收反应出现的时间。静脉注射三碘甲状腺原氨酸（60微克/天）或氢化可的松（10毫克/天）3天（每种情况各3只胎儿）后，所有胎儿在接触肾上腺素期间继续分泌肺液（三碘甲状腺原氨酸处理的胎儿分泌速率 = 5.9 ± 3.2毫升/小时，氢化可的松处理的胎儿分泌速率 = 4.4 ± 1.9毫升/小时）。然而，当以相同剂量将这两种激素同时给予3只胎儿时，观察到对肾上腺素有显著的重吸收反应（吸收率 = -12.3 ± 3.6毫升/小时），类似于在成熟胎儿中观察到的情况。诱导这种重吸收肺液的能力可能对新生儿呼吸问题的处理具有重要意义。
