Cassin S, DeMarco V, Perks A M, Kuck H, Ellis T M
Department of Physiology, College of Medicine, University of Florida, Gainesville 32610.
J Appl Physiol (1985). 1994 Sep;77(3):1445-50. doi: 10.1152/jappl.1994.77.3.1445.
The present studies were designed to test the hypothesis that arginine vasopressin (AVP) can interact with hydrocortisone and 3,5,3'-triiodothyronine (T3) to induce maturation of lung liquid reabsorptive processes in fetal sheep < 130 days gestation. Lung liquid production rates were measured in chronically catheterized thyroidectomized fetal sheep during eight different experimental treatments. Each experiment consisted of a 2-h control period followed by a 5-h treatment period. Net secretion or reabsorption of lung liquid was measured by using impermeant marker dilution techniques. AVP alone (50 mU/kg bolus plus 5.0 mU.kg-1.min-1 i.v. infusion) does not alter lung liquid secretion in fetal sheep 125 +/- 0.72 (SE) days gestation. In contrast, AVP (same dose as above) with T3 (30 micrograms) and hydrocortisone (6.94 mg/min) depressed lung liquid secretion and caused reabsorption of fluid. T3 alone, T3 and hydrocortisone, T3 and AVP, hydrocortisone alone, hydrocortisone and AVP, and saline did not result in net lung liquid reabsorption over a 5-h treatment period. These investigations demonstrate that AVP, T3, and hydrocortisone interact to cause lung liquid reabsorption in immature fetal lungs.
精氨酸加压素（AVP）可与氢化可的松及三碘甲状腺原氨酸（T3）相互作用，促使妊娠小于130天的胎羊肺液重吸收过程成熟。在8种不同的实验处理过程中，对长期插管的甲状腺切除胎羊的肺液生成速率进行了测量。每个实验包括一个2小时的对照期，随后是一个5小时的处理期。采用非渗透性标记物稀释技术测量肺液的净分泌或重吸收。单独使用AVP（50 mU/kg推注加5.0 mU·kg-1·min-1静脉输注）不会改变妊娠125±0.72（SE）天的胎羊肺液分泌。相比之下，AVP（与上述剂量相同）与T3（30微克）及氢化可的松（6.94毫克/分钟）可抑制肺液分泌并导致液体重吸收。单独使用T3、T3与氢化可的松、T3与AVP、单独使用氢化可的松、氢化可的松与AVP以及生理盐水在5小时的处理期内均未导致肺液净重吸收。这些研究表明，AVP、T3和氢化可的松相互作用可导致未成熟胎肺的肺液重吸收。
